Mechanisms of human DNA methylation, alteration of methylation patterns in physiological processes and oncology

A Sergeeva, K Davydova, A Perenkov, M Vedunova - Gene, 2023 - Elsevier
… of the genome with local hypermethylation is observed. In this review… DNA methylation and
demethylation in humans, the structure and distribution of CpG islands, the role of methylation

Advances in measuring DNA methylation

R Sun, P Zhu - Blood Science, 2022 - mednexus.org
DNA methylation helps maintain the stability of imprinted genes and the … DNA methylation
may cause a variety of diseases, such as tumors, vascular diseases, neurological diseases

[HTML][HTML] Universal DNA methylation age across mammalian tissues

AT Lu, Z Fei, A Haghani, TR Robeck, JA Zoller, CZ Li… - Nature aging, 2023 - nature.com
… , can be accurately estimated using DNA methylation profiles, the … development of universal
pan-mammalian clocks, using 11,754 methylation arrays from our Mammalian Methylation

[HTML][HTML] Epigenetic DNA methylation signatures associated with the severity of paget's disease of bone

I Diboun, S Wani, SH Ralston… - Frontiers in Cell and …, 2022 - frontiersin.org
… and genetic components, investigating DNA methylation patterns in PDB patients is of great
… identify associations between DNA methylation levels and the extent of disease severity in …

Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function

JS Hawe, R Wilson, KT Schmid, L Zhou… - Nature …, 2022 - nature.com
DNA sequence variation and DNA methylation using blood samples from 3,799
Europeans and 3,195 South Asians. We identify 11,165,559 SNP–CpG associations (methylation

DNA methylation mediates development of HbA1c-associated complications in type 1 diabetes

Z Chen, F Miao, BH Braffett, JM Lachin, L Zhang… - Nature …, 2020 - nature.com
… Here, we show the involvement of epigenetic DNA methylation (DNAme) in metabolic … , and
with subsequent development of complications over an 18-yr period in the blood DNA of 499 …

[HTML][HTML] Navigating the DNA methylation landscape of cancer

A Nishiyama, M Nakanishi - Trends in Genetics, 2021 - cell.com
… patterns are maintained by the daughter DNA through a maintenance DNA methylation
novo DNA methylation and maintenance DNA methylation are important for normal development

DNA methylation profiling identifies epigenetic differences between early versus late stages of diabetic chronic kidney disease

A Lecamwasam, B Novakovic, B Meyer… - Nephrology dialysis …, 2021 - academic.oup.com
… We have identified distinct DNA methylation patterns between early and late diabetic CKD
patients as well as demonstrated novel findings of potential progressive methylation changes …

[HTML][HTML] Aberrant DNA methylation in acute myeloid leukemia and its clinical implications

X Yang, MPM Wong, RK Ng - International journal of molecular sciences, 2019 - mdpi.com
… In this review, we summarize the current knowledge of DNA methylation in normal … of
DNA methylation and the current therapeutic strategies of targeting DNA methylation in …

[HTML][HTML] DNA methylation in polycystic ovary syndrome: emerging evidence and challenges

YN Liu, Y Qin, B Wu, H Peng, M Li, H Luo… - Reproductive Toxicology, 2022 - Elsevier
DNA methylation and PCOS. It is expected to help accelerate the application of DNA methylation
… summarizes the relationship between DNA methylation and the development of PCOS. …