… our understanding of human carcinogenesis and aging. In … driven by random events that
change the methylation status … the genetic and epigenetic levels is detected in human cancers, …

… Epithelial ovarian cancer (EOC) has an established genetic … BRCA1 promoter methylation
increases familial and sporadic EOC … (DNAm), whose critical role in carcinogenesis was first …

… It is now well accepted that carcinogenesis and cancer … early exons of the gene) across
various human cancer types. … to replicate a methylation pattern that has formed at random), or …

… In conclusion, our study supports the key role of altered DNA methylation in NFPanNET
tumorigenesis, which is further supported by the associated gene expression changes in the …

… the aberrant DNA methylation changes in human cancers and … Genetic changes contributing
to tumorigenesis have been … For example, sporadic breast and ovarian cancers harbor …

… basic aspects of DNA methylation in tumorigenesis, along … stomach tumorigenesis in which
CDH1 promoter methylation … , in both hereditary [89] and sporadic [90] diffuse gastric cancer (…

… and has a wide variety of genetic uses. This issue explores … into DNA methylation dynamics
and remodeling in tumorigenesis. … the cancer genome occurring alongside hotspots of copy …

… subset of sporadic Wilms tumors loses DNA methylation at the … Studies of tumorigenesis in
rodents fed methyl-deficient diets … can also be affected by copy-number alterations (CNAs) in …

… Here we report the DNA methylation profile of 84 sporadic … a role for methylation in both
driving tumorigenesis and … based on copy number and somatic mutations, and highlight …

… different modes of epigenetic carcinogenesis: first, we … is specific to promoters, we created
random regions which did not … and GSTP1 promoter methylation with copy number alteration (…