[HTML][HTML] DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation
… the impacts of methylation aberration on tumorigenesis are still … -genetic drivers, early
analysis of DNA methylation focused … , we observed methylation to decrease when copy number …
analysis of DNA methylation focused … , we observed methylation to decrease when copy number …
Mitotic inheritance of DNA methylation: more than just copy and paste
X Ming, B Zhu, Y Li - Journal of Genetics and Genomics, 2021 - Elsevier
… global DNA methylome in mammalian cells. This review focuses on the maintenance of DNA
methylation patterns … in a more conservative way, and even sporadic methylation changes (…
methylation patterns … in a more conservative way, and even sporadic methylation changes (…
Use of DNA methylation profiling in translational oncology
V Ortiz-Barahona, RS Joshi, M Esteller - Seminars in cancer biology, 2022 - Elsevier
… played by epigenetics in carcinogenesis. Additionally, this … , its distribution is not random but
mainly restricted to the … the first epigenetic lesions found in human cancer [1]. The molecular …
mainly restricted to the … the first epigenetic lesions found in human cancer [1]. The molecular …
DNA methylation and chromatin modifiers in colorectal cancer
V Vymetalkova, P Vodicka, S Vodenkova… - Molecular aspects of …, 2019 - Elsevier
… Colorectal carcinogenesis is a multistep process involving the … have been observed in virtually
all types of human cancers. … the sporadic MSI CRC the mutator phenotype was caused by …
all types of human cancers. … the sporadic MSI CRC the mutator phenotype was caused by …
[HTML][HTML] Whole slide images reflect DNA methylation patterns of human tumors
… carcinogenesis has been extensively studied. High-throughput DNA methylation assays have
been used broadly in cancer … This heterogeneity is in part attributed to the diverse genetic …
been used broadly in cancer … This heterogeneity is in part attributed to the diverse genetic …
[HTML][HTML] The bright and dark side of DNA methylation: A matter of balance
M Borchiellini, S Ummarino, A Di Ruscio - Cells, 2019 - mdpi.com
… copy will be silenced by DNA methylation [67,68,69]. The … or gain of DNA methylation may
contribute to tumorigenesis, but … In summary, genetic and epigenetic alterations often coexist, …
contribute to tumorigenesis, but … In summary, genetic and epigenetic alterations often coexist, …
[HTML][HTML] Tumorigenesis mechanisms found in hereditary renal cell carcinoma: a review
… the main driver for tumorigenesis of VHL as well as sporadic and other forms of hereditary
RCC. … Of note, MET copy number increases cellular dedifferentiation, lymph node invasion and …
RCC. … Of note, MET copy number increases cellular dedifferentiation, lymph node invasion and …
[HTML][HTML] DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load
… of patients with different types of human cancers. In particular, … on a null distribution generated
by using random PMD genes … cell division causes genetic and epigenetic alterations that …
by using random PMD genes … cell division causes genetic and epigenetic alterations that …
DNA-methylation for the detection and distinction of 19 human malignancies
… the vast majority of human cancer related disease burden. … understanding, DNA methylation
in carcinogenesis results in … types, we retrained the random forest model to predict all 19 …
in carcinogenesis results in … types, we retrained the random forest model to predict all 19 …
The genetic and epigenetic landscape of early-onset colorectal cancer
… known somatic genetic alterations in EO tumors and discuss alterations in DNA methylation.
… problem, as the age of onset of cancer is younger in this group than in totally sporadic CRC. …
… problem, as the age of onset of cancer is younger in this group than in totally sporadic CRC. …