… throughout life and reflect changes during tumorigenesis. … learning algorithm such as the
Random Forest classifier [6]. The … within analysis of copy number by DNA methylation as well as …

… There are three main genetic pathways in sporadic CRC: the … APC is the primary driver gene
of CIN carcinogenesis in 60–80… methylation occurs across a wide range of human cancers, …

… DNA methylation regulates gene expression and contributes to tumorigenesis in the early
stages of cancer… CRC tumorigenesis occurs through the accumulation of genetic and …

… emerging DNA methylation changes in lung cancer tumorigenesis, … All human cancers
present epigenetic abnormalities. … , copy number variation loss, and promoter hypermethylation …

… cells that does not resemble the pattern found in seminomas, … Sporadic genetic aberrations
have been observed in long-… even a small number of tumorigenic cells, although these data …

… heterogeneity, the great versatility to perform genetic manipulation and drug testing and, …
the idea that human cancer organoids available at the ATCC resemble more the epigenetic …

… Human cancers arise from environmental, heritable and … tumors may represent sporadic
cancers arising independently … considered a total copy number of 4 and minor copy number of …

… Genetic and epigenetic changes underlie carcinogenesis, which … , the pattern of DNA
methylation can be inherited in the series … are attributed to somatic aberrations in sporadic tumors (…

… methylated template strand of DNA as a reference to copy … In such mice, random X-chromosome
inactivation begins … of human cancers, suggesting that transposon methylation is …

… in DNA methylation pattern and also enrichment of methylated … Colorectal cancer is seen
in forms including: Sporadic form … The expression and activity of KLF4 in human cancers are …