… between DNMT inhibitors and chemotherapeutic drugs make combining epigenetic therapy
and … Moreover, DNMT inhibitors can reverse epidermal growth factor (EGF) receptor (EGFR) …

… cancers. In order to promote the development of a DNA methyltransferase inhibitor as an
anti-tumor … the relationship between DNA methylation and tumor, the anti-tumor mechanism, the …

… (DNMTs) to specific genomic loci to promote DNA methylation [19,20,21]. On the … DNA
methylation and histone modification machinery critical for maintaining the cellular epigenetic …

… undergoing clinical stage investigations in different cancer … of the epigenetic therapy
through the implementation of emerging … DNA methylation is an epigenetic process that can be …

… Epigenetic modifications, including DNA methylation and demethylation and histone …
Hence, epigenetic therapy has emerged as a rapidly advancing field of cancer research. A …

… with crucial roles in epigenetic regulation. They have been considered as promising
therapeutic targets for the epigenetic treatment of cancer. Therefore, DNMT inhibitors (DNMTis) …

… of DNA methylation by DNMTs and specifically introduces this process in the context of tumor
… Similarly, Vendetti et al. proposed epigenetic treatments that target DNMTs and HDACs in …

… epigenetic therapies, these new agents are selective, and many are targeted to proteins which
are mutated or translocated in cancer… aberrant DNA methylation across numerous cancer …

… of hematological malignancies and has exhibited viable therapeutic potential for … functions
of enzymes in DNA methylation, histone acetylation and histone methylation during tumor …

… of DNA methylation has not been detected so far, there are a few ways to remove DNA
methylation. … , but also the enzyme for pre-mRNA splicing could be epigenetic therapeutic targets. …