… therapeutic response [39, 41,42,43,44,45]. An example of the … of DNA methylation in clinical
practice is the first epigenetic … cancer, are robustly demonstrating that epigenetic therapy has …

… ) onto chromatin, leading to DNA hypomethylation 77 . Indeed, PRMT6 … DNA methylation
in many human cancer cells, and PRMT6 depletion or inhibition restores DNA methylation. …

… FDA approval of various DNA methyltransferase inhibitors, collectively called DNA HMAs,
and histone deacetylase inhibitors (HDACi) has brought epigenetic therapy to the forefront of …

… This radiation resistance can be reversed by an epigenetic treatment, which is the use of
SAM, a methyl donor. The radiation sensitivity in MCF-7/DOX cells was promoted through use …

… their delight, tumor volume was significantly decreased in patients treated with methylation
inhibitors … By summarizing previous studies, we believe that epigenetic therapy affects tumor …

… and histone proteins are modified in ways that regulate accessibility and function, and an …
one hallmark of cancer. Epigenetic therapies seek to normalize DNA methylation patterns and …

… accessory proteins may also be efficacious targets for epigenetic therapies, as are
histone-modifying enzymes that regulate chromatin structure [147]. The development of plasmid …

… of DNA methylation at the BDNF promoter is being tested in clinical trials for the treatment of
… Furthermore, the usage of epigenetic therapy in combination with chemotherapeutics of a …

… DNA methylation is one of the most studied epigenetic marks and typically occurs at the
pyrimidine C5 position of cytosine residues by transferring a methyl group from S-adenosyl-l-…

… DNA methylation and certain histone modifications in epigenetic regulation of target genes.
… first steps in a pathway that erase DNA methylation [29]. In general, the precise balance of …