Cell-free nucleic acids and their emerging role in the pathogenesis and clinical management of inflammatory bowel disease

Z Kubiritova, J Radvanszky, R Gardlik - International Journal of Molecular …, 2019 - mdpi.com
… In addition, it was recently revealed that DNA methylation plays an important role in
autoimmune-related chronic inflammatory diseases [77]. DNA methylation is an important epigenetic

DNA methylation aberrant in atherosclerosis

Y Dai, D Chen, T Xu - Frontiers in Pharmacology, 2022 - frontiersin.org
… This review will discuss the abnormal changes of DNA methylation in AS, including genome-…
of epigenetic treatment, which may provide new direction and potential therapeutic targets …

Epigenetics in breast cancer therapyNew strategies and future nanomedicine perspectives

V Buocikova, I Rios-Mondragon, E Pilalis… - Cancers, 2020 - mdpi.com
epigenetic therapy of BC, focusing on the ability of epi-drugs to sensitize resistant cancer
cells to standard therapeuticDNA methylation occurring in the promoter regions inhibits gene …

Epigenetic mechanisms of resistance to immune checkpoint inhibitors

A Perrier, A Didelot, P Laurent-Puig, H Blons, S Garinet - Biomolecules, 2020 - mdpi.com
… We discussed earlier that altered DNA methylation profiles in cancer cells or immune cells
impinge on tumor-specific … Epigenetic treatments also target the linkage between DNA

Epigenetic modifications of c-MYC: Role in cancer cell reprogramming, progression and chemoresistance

H Fatma, SK Maurya, HR Siddique - Seminars in cancer biology, 2022 - Elsevier
… transcription factor, epigenetic therapy might be one of the … DNA methyltransferases (DNMTs)
catalyze DNA methylation and regulate gene expression involved in colorectal carcinoma (…

Epigenetics in hepatocellular carcinoma

GP Nagaraju, B Dariya, P Kasa, S Peela… - Seminars in cancer …, 2022 - Elsevier
… The DNA methylation plays a significant role in regulating gene expression. The epigenetic
DNA methylation … Even though the epigenetic therapeutic drugs targeting these pathways …

Conserved DNA methyltransferases: a window into fundamental mechanisms of epigenetic regulation in bacteria

PH Oliveira, G Fang - Trends in microbiology, 2021 - cell.com
DNA methylation is the epigenetic mark most commonly found … variety of functional roles,
including defense against foreign DNA, … DNA methyltransferases (MTases) are responsible for …

Drug resistance in colorectal cancer: An epigenetic overview

M Luo, X Yang, HN Chen, EC Nice, C Huang - … (BBA)-Reviews on Cancer, 2021 - Elsevier
… modification and DNA methylation. In this review, we discuss epigenetic regulation in CRC
… of preventing or reversing CRC drug resistance using epigenetic therapy in CRC treatment. …

The emerging role of the piRNA/piwi complex in cancer

Y Liu, M Dou, X Song, Y Dong, S Liu, H Liu, J Tao, W Li… - Molecular cancer, 2019 - Springer
… , functions, and emerging roles in cancer, providing new … and piwi proteins in cancer
diagnosis and clinical treatment. … global DNA methylation and inhibiting tumor suppressor p16 …

The epigenetic and transcriptional landscape of neuroendocrine prostate cancer

A Davies, A Zoubeidi, LA Selth - Endocrine-related cancer, 2020 - erc.bioscientifica.com
… fuel epigenetic/transcriptional changes as well as the current state of epigenetic therapies for
… In NEPC, perturbed DNA methylation patterning and expression of epigenetic remodeling …