… The functional significance of this acute microglia-neuron interaction and its potential role
in the … dynamics following formalin injection are dependent on microglial P2Y12 signaling. …

… dorsal horn (DH) have been reported to be pivotal in neuropathic pain induction in male
rodents … Moreover, inhibitors of key signaling molecules in the spinal cord microglia-to-neuron …

… that AAV9-mediated DREADD expression in rat spinal microglia could affect morphine-…
of-principle that Gi signaling in microglia can suppress their pro-inflammatory activation and …

… adaptors to initiate downstream signaling pathways leading to … In rats without zymosan-induced
inflammation, CCL2 … of spinal microglia by DREADDs significantly evokes pain …

… Furthermore, microglia of male rats were transfected with inhibitory Gi DREADDs and …
This finding indicates that the activation of inhibitory Gi DREADDs in spinal microglia can help …

… on microglia and trafficking immune cells in the lumbar spinal cords and on peripheral immune
cells of neuropathic PAE rats (… Drug [DREADD] system) or direct inhibition of specific pro-…

… Here, we took advantage of DREADD technology to … progenitor) signaling in these cells,
with implications for other … or hM4Di DREADDs were expressed in spinal cord microglia by …

… spinal microglia play an important role in the molecular mechanism underlying experimental
neuropathic pain (NP) in male rodents… hM4Di-signaling in CX3CR1 + microglia can exert an …

… and profound biopsychosocial implications, chronic pain is a … difference in microglial
activation between rodents and … kinase in spinal microglia is required for persistent pain after …

… use Gi and Gq DREADDs in rat microglia by viral expression [55, 56]. Spinal microglia were
… activation can attenuate pro-inflammatory signaling including through the nuclear factor of …