Correlation between drug loading content and biological activity: the complexity demonstrated in paclitaxel-loaded glycopolymer micelle system

C Cao, J Zhao, M Lu, CJ Garvey… - Biomacromolecules, 2019 - ACS Publications
… the question of how the drug-loading content will affect the in vitro … core and shell radius
influence the drug loading, but drugdrug-loading strategies of polymeric micelles: simultaneous …

Polymeric micelles for the delivery of poorly soluble drugs: From nanoformulation to clinical approval

D Hwang, JD Ramsey, AV Kabanov - Advanced drug delivery reviews, 2020 - Elsevier
… This could also greatly affect the quality of life of the patients [… drugs can also be chemically
conjugated to the core-forming … a polymeric micelle containing the conjugated drug in the core

Loading‐Dependent Structural Model of Polymeric Micelles Encapsulating Curcumin by Solid‐State NMR Spectroscopy

AC Pöppler, MM Lübtow… - Angewandte Chemie …, 2019 - Wiley Online Library
… a polymer micelle might be affected by the presence of drug … discs, no detectable dissolution
was observed for crystalline … with the hydrophobic micellar core are largely saturated (Figure …

Hypoxia-responsive stereocomplex polymeric micelles with improved drug loading inhibit breast cancer metastasis in an orthotopic murine model

M Lu, X Huang, X Cai, J Sun, X Liu… - … Applied Materials & …, 2022 - ACS Publications
… by exploiting chemical cross-linking of either core or shell … Drug loading had an insignificant
effect on the D h , PDI, and … with a high drug loading can facilitate drug accumulation in …

Exploring optimized methoxy poly (ethylene glycol)-block-poly (ε-caprolactone) crystalline cored micelles in anti-glaucoma pharmacotherapy

E Elmowafy, H Gad, F Biondo, L Casettari… - International Journal of …, 2019 - Elsevier
… The utilization of polymeric micellar structures has been … micelles with greater core and
larger size accommodating more … M w and D/P ratio exhibited a significant antagonistic effect on

Improved Core Viscosity Achieved by PDLLA10kCo-Incorporation Promoted Drug Loading and Stability of mPEG2k-b-PDLLA2.4k Micelles

C Guo, Y Zhang, H Yuan, Y Zhang, T Yin, H He… - Pharmaceutical …, 2022 - Springer
… payload in polymeric micelles are to enhance the drug-coredrug loading by altering the
microstructure of the micelle core. … than that of PEG-b-PCL micelles with semi-crystalline core (…

Advances in polymeric and lipid-core micelles as drug delivery systems

T Musacchio, VP Torchilin - Polymeric biomaterials, 2020 - api.taylorfrancis.com
… be illustrating lipid-core and polymeric micelles as drug carriers since … surroundings, while
reducing undesirable side effects on … , the excess drug precipitates in a crystalline form and is …

Ultra‐High to Ultra‐Low DrugLoaded Micelles: Probing Host–Guest Interactions by Fluorescence Spectroscopy

MM Lübtow, H Marciniak, A Schmiedel… - … A European Journal, 2019 - Wiley Online Library
… Here, we compare two isomeric polymer micelles, one of … with some polymer chains in
between preventing crystallization. … significantly affect the interactions between drug and polymer, …

Like dissolves like? A comprehensive evaluation of partial solubility parameters to predict polymerdrug compatibility in ultrahigh drug-loaded polymer micelles

MM Lübtow, MS Haider, M Kirsch, S Klisch… - …, 2019 - ACS Publications
… hydrophobic core of polymeric micelles as … affects the stability of the remaining
nanoformulations. However, important to note, the precipitate does presumably not comprise …

Polymeric micelles and cancer therapy: An ingenious multimodal tumor-targeted drug delivery system

SK Hari, A Gauba, N Shrivastava, RM Tripathi… - Drug Delivery and …, 2023 - Springer
… or export of drugs from single cells may be affected by the … This further facilitates the production
of the permeability factors of … core and outer hydrophilic shell above CMC and CMT. Such …