Cerebellar dysfunction as a source of dystonic phenotypes in mice

AM Brown, ME van der Heijden, HA Jinnah, RV Sillitoe - The Cerebellum, 2023 - Springer
… are less severe, the mice are compromised in their motor … Purkinje cell simple spike activity
is slower and is more tonic … of a different mouse model in which granule cell neurogenesis is …

Acetylcholine modulates cerebellar granule cell spiking by regulating the balance of synaptic excitation and inhibition

TR Fore, BN Taylor, N Brunel - Journal of Neuroscience, 2020 - Soc Neuroscience
granule cell layer synaptic integration in male rats and micecells decreases phasic and
tonic inhibition in granule cells. A, … reduces both excitatory and inhibitory inputs to granule cells, …

Cerebellar granule cell

E D'Angelo - Handbook of the cerebellum and cerebellar disorders, 2021 - Springer
… neurotransmitter spillover and accumulation, causing tonic inhibition, and favors crosstalk
… In NR2A-Cδc /ΔC mice, NMDA receptor opening probability is reduced and the threshold for …

The role of tonic glycinergic conductance in cerebellar granule cell signalling and the effect of gain‐of‐function mutation

C McLaughlin, J Clements… - The Journal of …, 2019 - Wiley Online Library
… in cell cultures and in living cerebellar tissue of C57Bl-6J mice. We found that GlyRs of CGCs
deliver a significant amount of tonic inhibition not continuously, but when the cerebellarlow

[HTML][HTML] Potential interactions between cerebellar dysfunction and sleep disturbances in dystonia

LE Salazar Leon, RV Sillitoe - Dystonia, 2022 - frontierspartnerships.org
… a lower frequency of cerebellar nuclei firing and Purkinje cells that … mouse possesses a
mutation in P/Q-type calcium channels expressed in cerebellar granule cells and Purkinje cells

Mice with monoallelic GNAO1 loss exhibit reduced inhibitory synaptic input to cerebellar Purkinje cells

H Feng, Y Yuan, MR Williams, AJ Roy… - Journal of …, 2022 - journals.physiology.org
disorder animal model with monoallelic Gnao1 loss. This study illustrates the role of Gα o
protein in regulating GABA release in mouse cerebellum. … there is no tonic regulation of GABA …

GABA tone regulation and its cognitive functions in the brain

W Koh, H Kwak, E Cheong, CJ Lee - Nature Reviews Neuroscience, 2023 - nature.com
… GABA on excitatory granule cells in the cerebellum and hippocampus, termed tonic inhibition
2,… Conversely, knocking out Mao-b in mice not only decreased cerebellar and striatal GABA …

Motor performances of spontaneous and genetically modified mutants with cerebellar atrophy

R Lalonde, C Strazielle - The Cerebellum, 2019 - Springer
cell innervation and mild depletion of cerebellar granule cells, resulting in cerebellar ataxia
and a hopping gait reminiscent of micereduced Purkinje cell dendritic arborization and lower

Ion channel dysfunction in cerebellar ataxia

DD Bushart, VG Shakkottai - Neuroscience letters, 2019 - Elsevier
… In these mice, the lack of K v 3.3 current reduces the slope of … to impaired neurotransmission
from cerebellar granule cells [99]. … in the maintenance of tonic firing in Purkinje neurons. …

GABA and synaptic transmission in the cerebellum

T Hirano - Handbook of the cerebellum and cerebellar disorders, 2021 - Springer
mice lacking Purkinje or Golgi cells and those with reducedcells by granule cells and inhibition
of granule cells by Golgi … mechanism such as tonic inhibition of granule cells by α6 and δ …