Respiratory syncytial virus exacerbates kidney damages in IgA nephropathy mice via the C5a-C5aR1 axis orchestrating Th17 cell responses

X Hu, J Feng, Q Zhou, L Luo, T Meng… - Frontiers in cellular …, 2019 - frontiersin.org
… sections of kidneys from all experimental mice were examined. … Moreover, there was research
proposed that C5aR-deficient … that RSV infection might promote HMC antigen presentation …

Mesangial deposition can strongly involve innate-like IgA molecules lacking affinity maturation

B Wehbi, C Oblet, F Boyer, A Huard… - Journal of the …, 2019 - journals.lww.com
IgA nephropathy (IgAN) is characterized by IgA mesangial … Among several existing IgAN
experimental models, none … This results in the formation of bulky nephritogenic immune …

The emerging role of complement proteins as a target for therapy of IgA nephropathy

DV Rizk, N Maillard, BA Julian, B Knoppova… - Frontiers in …, 2019 - frontiersin.org
… may distinguish isolated from nephritogenic IgA deposition. Notably, the … In an experimental
model of IgAN, mice deficient for C3 and … vaccine at least 2 weeks prior to therapy initiation. …

Gut microbiota and bacterial DNA suppress autoimmunity by stimulating regulatory B cells in a murine model of lupus

Q Mu, MR Edwards, BK Swartwout… - Frontiers in …, 2020 - frontiersin.org
… This work suggests that a form of oral tolerance induced by … In mouse studies, the initial
finding that B cell-deficient lupus-… However, direct experimental evidence is lacking to support …

IgA Nephropathy: Pleiotropic impact of Epstein-Barr virus infection on immunopathogenesis and racial incidence of the disease

J Mestecky, BA Julian, M Raska - Frontiers in Immunology, 2023 - frontiersin.org
… to formation of nephritogenic circulating immune complexes. … into immune-deficient mice
induced kidney pathology features … genetic burden promoted an earlier onset of disease (46). …

Emerging immunotherapies for autoimmune kidney disease

MH Foster, JR Ord - Human Vaccines & Immunotherapeutics, 2019 - Taylor & Francis
experimental GN: IVIG protects mice from nephrotoxic serum … Lamm and colleagues used
an IgA nephropathy model … and mediators of nephritogenic autoimmunity will accelerate …

[HTML][HTML] Epitope Spreading in Immune-Mediated Glomerulonephritis: The Expanding Target

CT Strizzi, M Ambrogio, F Zanoni, B Bonerba… - International Journal of …, 2024 - mdpi.com
… , consistent with serum dilution experiments that indicated that … IgA nephropathy has been
traditionally recognized as a … ], which enhances binding to the galactose-deficient glycans of gd…

Monitoring immune responses in IgA nephropathy: biomarkers to guide management

H Selvaskandan, S Shi, S Twaij, CK Cheung… - Frontiers in …, 2020 - frontiersin.org
experimental evidence that each of these lesions associates with known pathogenic pathways
triggered by mesangial deposition of IgAIgA levels some investigators have promoted the …

Targeting APRIL in the treatment of glomerular diseases

CK Cheung, J Barratt, R Lafayette, A Liew, Y Suzuki… - Kidney International, 2024 - Elsevier
… , with a focus on IgA nephropathy where the clinical development of … of Galactose deficient-IgA1
(Gd-IgA1) in IgA nephropathy. … Experimental evidence demonstrates a link between TLR …

Generation of tolerogenic dendritic cells from Fcgr2b deficient lupus-prone mice for the model of SLE therapy

P Khiewkamrop - 2022 - digital.car.chula.ac.th
… Purified CD3+ T cells were isolated from OVA-immunized both mice (wild type and deficient
… in vitro experiment for further in vivo induction of tolBMDCs in the subsequent experiments. …