… process of lymphatic remodeling and maturation, mechanisms … Tie1 deficient mice also
showed similar defects with mural … activated Wnt-angiopoietin-2 signaling recapitulates vascular …

… for the remodeling and maturation of the blood and lymphatic … -deficient mouse embryos
suffer from remodeling defects of … breast cancer model induced by angiopoietin-2. J Pathol 217(…

… role in lymphatic development in vivo, as Ang2-deficient mice presented … defects on the
collecting lymphatic vessels and valves, deficient postnatal remodeling of the dermal lymphatic …

… This project uses lymphatic-deficient mice (Angiopoietin-2 [Ang2] knockout) to … a
defective/poorly functioning lymphatic system might protect the colon against cancer development …

… identified primary tumor–derived Angiopoietin-2 (Ang2) as a … been shown to inhibit lymphatic
remodeling and valve formation … lymphatic defects due to impaired lymphatic maturation …

… ; Angpt, mouse) regulates vascular remodeling in development and … that defects in Angpt2
+/443 and Angpt2 443/443 mice are … to Angpt2-deficient mice. In contrast with Angpt2 443/443 …

… skin lymphatic development in embryos and caused abnormal lymphatic remodeling in adult
mice. … HIF-2α expression may regulate lymphatic development by controlling TIE2 signaling. …

… Increased expression of downstream targets in these pathways, ANGPT2 (angiopoietin-2)
and DSCR (Down syndrome critical region protein) 1.4 were confirmed by quantitative PCR …

… This finding is consistent with the atrophy and increased apoptosis we found in defective
postnatal collecting lymphatic vessel development in Tie1/-2–deleted mice. Perhaps Ang2 can …

… in angiopoietin 2 (ANGPT2), which is involved in lymphatic … and functional defects of the
lymphatic vascular system that … lymphatic vessel remodeling during embryonic and postnatal …