… of HSC and liver fibrogenesis are NOX1, NOX2, and NOX4 [55,… to p47 phox -deficient mice,
less liver damage and hepatic free … FXR activity is a major inhibitor of HCC. Whole-body FXR-…

… NOX4-deficient mice show decrease in epithelial cell … the first small molecule inhibitor
targeting NOX1/NOX4 (133). … balance through inhibition of TGF-β1-induced NOX4 activity and …

… –2) [7], NOX1, NOX2, and NOX4 are expressed in the liver [8]. … deficiency suppresses NOX4
expression through inhibiting the … reducing ROS production and ameliorating liver fibrosis. …

… Various isoforms, such as NOX1, NOX2, and NOX4, are distinctively expressed in specific
… NOX1 inhibition does not prevent HCC development in mice. In order to induce HCC, …

… -choline deficient diet) diet were used to induce liver fibrosis. … NOX has seven isoforms
(NOX1-NOX5, DUOX1 and DUOX2)… showed that NOX4 expression in mice with liver fibrosis was …

… novel strategies to prevent aging-related liver fibrosis. … is composed of the membrane subunit
(NOX1-5), p22phox and the … effect on neuronal damage via inhibition of oxidative stress-…

… this study we show that NOX1, but not NOX4, is required for DEN… To investigate the impact
of NOX1 deficiency on these … of NOX1, but not NOX4, inhibited HCC formation in mice. These …

… liver fibrosis and hepatic stellate cell activation by inhibiting the TGF-β1/Smad and NOX4/…
Ethanol + CCl 4 -induced SD rats in vivo and TGF-β1- stimulated human hepatic stellate LX-2 …

… -induced hepatic oxidative stress via inhibiting hepatic NOX4 … During liver fibrosis,
NLRP3-deficiency in mice showed no … a possible anti-fibrotic effect by preventing hepatic necrosis …

… was prevented in NOX2 deficient mice, indicating their role in tissue repair [22]. NOX4 has …
, such as those aiming to use NOX1/NOX4 inhibitors to slow the progression of fibrosis [54,55] …