… maturation may impair oocyte fertilization during IVF (Fig. 1). … Likewise, mitochondrial
transcription factor A knockout mice … of meiotic spindle formation and poorer embryo quality (55). …

… FSH deficiency in humans due to hypogonadotropic … Here, we further examined whether
excessive FSH affects the oocyte … ATP, has been shown to cause spindle disassembly in …

… oxidative stress, resulting in meiotic spindle abnormalities. … the oocytes from the deleterious
effects of oxidative stress, … These results show that Nrf2 deficiency in mice females has a …

… and ATP content of in vivo matured bovine oocytes. We hypothesized that in vivo matured
oocytes from … In mice, a positive correlation was observed between the ATP content of mature …

… play a vital role in ATP synthesis, oxidative stress, apoptosis, … for aberrations in meiotic
spindle assembly, abnormal … , mitochondria in oocytes are extremely enriched during the …

… FSH deficiency in humans owing to hypogonadotropic … Here, we further examined whether
excessive FSH affects the oocyte 586 … ATP, has been shown to cause spindle disassembly in …

… Suboptimal culture conditions may impair the ability of the oocyte to … Oxidative stress is a
critical factor disrupting the proper … For instance, the ATP generated by the mitochondria powers …

… stage, mature Oocytes (MII), fertilized Oocytes, Energy required … ATP production through its
role in the ATP synthase structure. … meiosis in cultured mouse oocytes. Proceedings National …

… oxidative balance seems to be critical for oocyte quality in advanced-maternal-age patients;
however, we still need more studies on oxidative stress … antioxidant capacity affects gamete …

… with 25 µM H2O2 and observed increase in oxidative stress and also mild spindle defects …
Deficit of mitochondria-derived ATP during oxidative stress impairs mouse MII oocyte spindles. …