… changes occur deterministically and drive the cancer phenotype, in vitro models and human
cancers have shown that DNAme changes … , whose hypermethylation defined the subset …

… [64], the mechanisms driving the initial change in DNA methylation patterning either as a …
Global measurement of DNA methylation defines the total amount of 5-methylcytosine relative …

… We defined hypermethylation as beta values greater than 0.5, … We also explored the DNA
methylation status of driver genes … DNA methylation and gene expression data in human cancer…

… has never been defined. Through whole-genome bisulfite … , we discovered alterations
affecting driver genes that were detectable … Approximately half of prostate cancers are defined by …

… Determining DEGs affected by methylation changes is a research problem of dealing
with high dimensional feature spaces that need s to combine gene expression levels …

… lung cancer subtypes, the mutational status of cancer driver … current knowledge of DNA
methylation related to lung cancer, … could assist in better defining lung cancer subtypes (SCLC vs. …

… in human cancers. However, knowledge of the impact of DNA methylation changes on lung
… normal lung tissues for 15 chromatin states which were defined in ESCs 6 . We found that …

… The DNA methylation landscape of human cancers is … 16,17) environmental exposures,(18)
driver alterations,(19) deregulated … However, ICA allowed us to define more DNA methylation …

… such epi-driver changes, we recently proposed an analytical framework to identify and assign
functional significance to putative epi-drivers of metastasis [7]. We defined epi-drivers to be …

… , and DNA methylation arrays from more than 1400 human cancers, we … DNA methylation
array probes for 11,203 CpG islands (CGIs), defining the top CGI probes for each cancer …