… Cas9 nuclease (derived from Streptococcus pyogenes) … ) polymerase chain reaction (PCR)
and Sanger sequencing (8,9). … examined what other factors might influence LD formation. At …

… for the mutant allele, we derived two embryonic stem cell (ESC) … Although this does not rule
out all deletions, deletions of a few … a translocation would affect two or more chromosomes. …

… of de novo deletions do not seem to have a major impact.51 … acid is a diffusible
mesenchymal-derived signal that influences … repertoire diminish the diversity of potential …

… result in less severe signs of HED and nearly normal sweating. In the patients with these
variants, the in-frame deletion … polymerase slippage but would not affect the multimerization and …

… We assessed the impact of RT and/or TMZ on the somatic … We evaluated whole-genome
sequencing-derived mutational … This work extends our knowledge on the genomic response …

… To dissect the mechanisms by which 4C4 deletions influence PDAC phenotypes, we performed
RNA-… Analysis of an experimentally derived type I IFN response signature (Methods and …

… suppression, but deletion of the entire arm was necessary to … evaluated CN influence on
immune profiles and outcomes in … response and resistance to immunotherapy include deletion …

… genome editing can cause local DNA rearrangements and deletions up to several … , we did
not detect LOH that would be suggestive of chromothripsis in hematopoietic colonies derived …

… was defined by the presence of blunt ends, small deletions … breakpoint of derivative 1 and
to the breakpoint of derivative 14, … We then explored the general impact of breakpoints on the …

… chromosome loss (that is, an interstitial or terminal deletion) … has consequences specific to
T cell fate and does not affect … and possibly antigen-specific responses 129 . In the context of …