Notch-regulated dendritic cells restrain inflammation-associated colorectal carcinogenesis

L Wang, S Yu, ER Chan, KY Chen, C Liu, D Che… - Cancer immunology …, 2021 - AACR
cancer in mice. Through database analysis, we identified a link between Notch2 and cDC1
in human colorectal cancer … impact of fucosylation deficiency in human colorectal cancer by …

Dendritic cell paucity in mismatch repair–proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy

WW Ho, IL Gomes-Santos, S Aoki… - Proceedings of the …, 2021 - National Acad Sciences
cells grown as liver metastases and subcutaneous tumors. We found a paucity of both activated
T cells and dendritic cells … Our findings also posit dendritic cells as antitumor components …

[HTML][HTML] CXCL8 associated dendritic cell activation marker expression and recruitment as indicators of favorable outcomes in colorectal cancer

E Li, X Yang, Y Du, G Wang, DW Chan, D Wu… - Frontiers in …, 2021 - frontiersin.org
colorectal cancer (CRC) patients from The Cancer Genome Atlas (TCGA) database. An
integrated gene profile and functional analysis of TIC proportions revealed that the dendritic cell (…

The role of dendritic cells in cancer

YS Lee, KJ Radford - International review of cell and molecular biology, 2019 - Elsevier
… immunotherapy harnesses the ability of the immune system to recognize and eliminate
cancer. The potent ability of dendritic cells (DCs) to initiate and regulate adaptive immune …

[HTML][HTML] … cytotoxic effector cells towards cholangiocellular, pancreatic, and colorectal tumor cells by activation of the immune checkpoint CD40/CD40L on dendritic cells

F Sadeghlar, A Vogt, RU Mohr, R Mahn… - Cancer Immunology …, 2021 - Springer
… , pancreatic carcinoma, and metastatic colorectal carcinoma, … cancer, cholangiocarcinoma,
and colorectal cancer have … when GI tumors presented a mismatch repair deficiency (MSI-…

[HTML][HTML] Dendritic cell subsets in cancer immunity and tumor antigen sensing

A Del Prete, V Salvi, A Soriani, M Laffranchi… - Cellular & molecular …, 2023 - nature.com
… colitis-associated colorectal cancer, which showed high susceptibility to tumor formation [94].
In a mouse model of intracranial glioma with type I IFN receptor deficiency, the acceleration …

[HTML][HTML] Dendritic cells in cancer immunology

TL Murphy, KM Murphy - Cellular & molecular immunology, 2022 - nature.com
… Specifically, this review covers three aspects of dendritic cell (DC) biology connected with
antitumor immune responses but are not specifically oriented toward therapeutic use. First, we …

… 2 by dendritic cells prevents their expression of interleukin 27 and is required for maintenance of mucosal barrier and immune response against colorectal tumors in …

S Lavoie, E Chun, S Bae, CA Brennan, CAG Comeau… - Gastroenterology, 2020 - Elsevier
Intestinal microbes and their metabolites affect the development of colorectal cancer (CRC).
Short-chain fatty acids are metabolites generated by intestinal microbes from dietary fiber. …

[HTML][HTML] The immune landscape of colorectal cancer

A Mezheyeuski, P Micke, A Martin-Bernabe… - Cancers, 2021 - mdpi.com
… This approach has disadvantages, as low abundance cell types are challenging to quantitate
… NKT cells correlated negatively to mature dendritic cells and plasmacytoid dendritic cells (…

[HTML][HTML] Colorectal cancer immune infiltrates: significance in patient prognosis and immunotherapeutic efficacy

L Guo, C Wang, X Qiu, X Pu, P Chang - Frontiers in immunology, 2020 - frontiersin.org
Colorectal cancer occurrence and progression involve multiple aspects of host immune
deficiencies… effector functions of dendritic cells and other CD4 + T cell subsets (Th1, Th2, or Th17 …