… -κB activity in pathogenesis of amyotrophic lateral sclerosis (… in mice expressing TDP-43
A315T or TDP-43 G348C mice … remained unknown whether deregulated NF-κB signaling within …

… the relationship between TDP-43 and immune-mediated pathways. … and the deregulation
of TDP-43 may contribute to ALS … TDP-43 and trigger the inflammatory response observed in …

… Cytoplasmic inclusions of transactive response DNA binding protein of 43 kDa (TDP-43) in
… TDP-43 (FTLD-TDP) and amyotrophic lateral sclerosis (ALS). However, the role of TDP-43 in …

… from the TDP-43 monomers function as seeds and trigger coaggregation and sequestration
of … of TDP-43 WT – and TDP-43 6M –mediated toxicities, we assessed the splicing function of …

… TDP-43) is a multifunctional RNA binding protein directly implicated in the etiology of amyotrophic
lateral sclerosis (ALS… pro-inflammatory transcription factor nuclear factor kappa B (NF-…

… motor neurons of patients with amyotrophic lateral sclerosis (ALS) where TDP-43 re-locates
from … Further, we showed an induced cellular stress which causes reduced TDP-43 nuclear …

… TDP-43 could also have a contribution to this deregulation of … well-known genetic causes
of ALS such as the superoxide … TDP-43 is not a requisite for TDP-43-mediated toxicity in ALS…

… feature common to amyotrophic lateral sclerosis (ALS) and … Most signals that trigger the
NF-κB signaling pathway converge on … CUL2-mediated clearance of misfolded TDP-43 is …

… diseases including amyotrophic lateral sclerosis (ALS), … Moreover, TDP-43 deregulation
can also provoke hyperactive … from this new TDP-43-mediated pathogenic pathway. One …

… diseases including amyotrophic lateral sclerosis (ALS) and … Recently, we reported that
AAV-mediated delivery of a single-… TDP-43 proteinopathy can cause translational deregulation …