[HTML][HTML] From DNA human sequence to the chromatin higher order organisation and its biological meaning: using biomolecular interaction networks to understand the …

M Chiliński, K Sengupta, D Plewczynski - Seminars in cell & developmental …, 2022 - Elsevier
… a significant functional impact on gene expression. The high-… mediated by the CTCF protein
detected in a ChIA-PET … on the genome's mesoscale network structure. They also explain …

[HTML][HTML] Protein complex prediction: A survey

J Zahiri, A Emamjomeh, S Bagheri, A Ivazeh… - Genomics, 2020 - Elsevier
… In this article, most important computational methods for proteinontology annotations and
gene expression profiles with those … information and/or network structure to detect conserved …

[HTML][HTML] A comparative study of cluster detection algorithms in proteinprotein interaction for drug target discovery and drug repurposing

J Ma, J Wang, LS Ghoraie, X Men… - Frontiers in …, 2019 - frontiersin.org
data, we first accessed the normalized gene expression in the … entire network topology
propriety and perturbation data to … genes that participate big functional clusters are important for …

Integrated network analysis and machine learning approach for the identification of key genes of triple‐negative breast cancer

LD Naorem, M Muthaiyan… - Journal of cellular …, 2019 - Wiley Online Library
… integration of various gene expression data sets. Additionally… This package detects outlier
samples based on three quality … parameters that describe the network topology such as degree …

Integration of multiomics data with graph convolutional networks to identify new cancer genes and their associated molecular mechanisms

R Schulte-Sasse, S Budach, D Hnisz… - Nature Machine …, 2021 - nature.com
… type of data—either multiomics features or the network topology. … data, we found that the
sensitivity of EMOGI in detecting KCGs … , DNA methylation and gene expression data of 29,446 …

Network-based identification genetic effect of SARS-CoV-2 infections to Idiopathic pulmonary fibrosis (IPF) patients

TA Taz, K Ahmed, BK Paul, M Kawsar… - Briefings in …, 2021 - academic.oup.com
… GEO database was introduced for gene expression analysis … it contains 11 methods for
topological analysis [38]. The hub … of this study including hub gene detection for identifying drug …

[HTML][HTML] Detection of molecular signatures and pathways shared in inflammatory bowel disease and colorectal cancer: a bioinformatics and systems biology approach

M Al-Mustanjid, SMH Mahmud, MRI Royel… - Genomics, 2020 - Elsevier
… Also, we have identified crucial pathways, hub proteins, and … from JASPAR database based
on topological analysis using … We analyzed the gene expression microarray data from NCBI…

[HTML][HTML] Comparative analyses of gene co-expression networks: Implementations and applications in the study of evolution

K Ovens, BF Eames, I McQuillan - Frontiers in Genetics, 2021 - frontiersin.org
… The increasing abundance of gene expression data makes GCNs … Differential co-expression
analysis also detects differences … evolution, comparing network structure without relying on …

Integrated bioinformatics analysis of expression and gene regulation network of COL12A1 in colorectal cancer

Y Wu, Y Xu - Cancer medicine, 2020 - Wiley Online Library
genetic alterations correlated with tumorigenesis and progression is essential for identifying
new … .26, 27 Alterations of COL12A1 gene in chromosomal structure can cause its aberrant …

[HTML][HTML] A linear regression and deep learning approach for detecting reliable genetic alterations in cancer using dna methylation and gene expression data

S Mallik, S Seth, T Bhadra, Z Zhao - Genes, 2020 - mdpi.com
… We provided detail hub gene network structure in a Supplementary File, Additional file 7: …
hub genes detected by our method played an important role in the respective cancer. PAIP 2 …