… and mechanotransduction of striated muscle. While recent evidence suggests that microtubules
enriched in detyrosinated α-… are evident in healthy cardiac and skeletal muscle, both are …

… microtubules in the heart are C-terminal detyrosination and luminal acetylation, both of which
are induced in heart … to increase microtubule flexibility 5 ) or modulation of interactions with …

… reactions in healthy muscle can modulate blood supply, … skeletal muscle were expanded
further into the heart. In the … changes to microtubule density, levels of detyrosination, and …

… disorganization and detyrosination, and altered mechanical … stress in both cardiac and skeletal
muscle. Upregulation of the β-… in nuclear homeostasis and cardiac mechanotransduction. …

… Reinforcing the importance of treating cardiac dysfunction as well as skeletal muscle … of
improving skeletal muscle tissue without addressing the underlying cardiac issues present in …

… likely to modulate in turn the nuclear mechanotransduction, … modifications such as increased
detyrosinated [75,76] and … found almost exclusively in skeletal and cardiac muscle [122,…

… detyrosinated population of microtubules was also found to be essential for mechanotransduction
in muscle … Live imaging of t-tubule formation in zebrafish skeletal muscle demonstrated …

… and characterized a mechanotransduction pathway by which … Our initial works identified
that the level of detyrosinated tu… in skeletal muscles, we examined hindlimb skeletal muscle of …

… by detyrosination, are also pathognomonic of skeletal muscle … level of PTM also modulates
mechanotransduction. Our lab’s … detyrosination in regulating mechano-signaling in skeletal …

… -tubulin molecules were tyrosinable in skeletal muscle [38]. An … status of microtubules is long
known to modulate interaction … review for cardiomyocyte/heart and neuron/brain physiology. …