… Polyunsaturated fatty acids (PUFAs) form cellular, … However, PUFAs are susceptible to the
noxious lipid peroxidation (LPO) … , is used by the brain to recycle damaged lipids in bilayers [ …

… brain consumes around 20% of oxygen despite making only 2% of body weight. The brain is
rich in polyunsaturated fatty acids (PUFAs) … to prevent the accumulation of lipid peroxides in …

… Lipid peroxidation (LPO) plays a key role in many age-related neurodegenerative … The
introduction of deuterated polyunsaturated fatty acids (D-PUFA) into membrane lipids is a …

… Cerebral lipid peroxidation was found to be an early event in … in the cortex and hippocampus
compared to H-PUFAs [51]. … administration may reduce or prevent brain amyloidosis [200]. …

… that prevent PUFA depletion in the brain may prevent AD … were obtained using deuterated
fatty acid standards All CSF … comparing fatty acids in each CSF fraction with CSF amyloid and T…

… of amyloid peptides seen in the Alzheimer’s brain tissues … that the hippocampus, striatum,
cerebellum and cerebral cortex … inhibition of lipid peroxidation will reduce the development of …

… that a single amino acid of phenylalanine can self-assemble into fibrils with amyloid-like …
the hippocampus of model mice and in the parietal cortex brain tissue of PKU patients [37]. …

… on the roles of HNE associated with amyloid β-peptide (Aβ) … allylic H-atoms were replaced
by allylic deuterium-atoms, and … ), and for thickness of hippocampus and frontal cortex (MRI) …

… tau hyperphosphorylation and β-amyloid protein (Aβ) formation, as … to changes in the
hippocampus and cerebral cortex lipidomes. … with increased lipid peroxidation and ROS …

… amyloid beta in the same AD mouse model [12] and amyloid … the hippocampus of untreated
AD mice. CMS121 treatment … : identical amounts of deuterated internal standards were …