… Angiogenesis is critical to cancer development and metastasis. However, anti-angiogenic
agents … vessels per bead in a 3-dimensional bead assay of sprouting angiogenesis [33] (Fig. 2a…

… in vitro assays using tumor and endothelial cells, along with … both anti-cancer and anti-angiogenic
activity that should be … requires 3D cell interactions, the multicellular spheroid model …

… tumor endothelial cells, and many angiogenesis inhibitors have also been developed [3]. …
showed improved inhibitory effects on HUVECs, HUVEC 3D tubes in vitro and a subcutaneous …

… human cerebral microvascular endothelial cells can be inhibited … Angiogenesis is the process
referred to the vessel growth, but … In tumor angiogenesis, endothelial cell migration occurs …

… is a need to identify novel anti‑angiogenic agents. In the last … of endothelial cells (paracrine
regulation) and tumor cells (… tumor growth and angiogenesis in a mouse xenograft model (…

… in tumor growth and metastasis and anti-angiogenic therapy, this … Ultimately, the interaction
between angiogenic factors and TME … angiogenesis follows the activation of endothelial cells …

… of proper in vitro angiogenesis models comprising mature and … coculture model of human
umbilical vein endothelial cells (… , we report the development of an indirect coculture model of …

… to brain tumour development, providing … angiogenesis is the result of the interaction of
multiple TME components. Thus, targeting the TME may provide new ideas for the anti-angiogenic …

… and anti-angiogenic factors formed by the host cells as well … of the endothelial cells, tumor
angiogenesis, tumor growth, and … activity based on the developed 3D-QSAR model. Further, in …

… to endothelial cells (ECs) to promote tumor angiogenesis. … , several anti‐angiogenic drugs
have been developed and … Furthermore, VEGF 90k on the surface of EVs interacts well with …