Cortical cellular diversity and development in schizophrenia

AJ Price, AE Jaffe, DR Weinberger - Molecular psychiatry, 2021 - nature.com
development are governed by the transcriptome and epigenome, two levels of gene regulation
that have the potential to reflect both genetic … direction for illuminating genome regulation

Cortical gene expression architecture links healthy neurodevelopment to the imaging, transcriptomics and genetics of autism and schizophrenia

…, Lifespan Brain Chart Consortium… - Nature …, 2024 - nature.com
… Leveraging independent RNA-seq datasets on single-cell and developmental gene
expression, we further demonstrate that all three components are generalizable to other datasets, …

Regional heterogeneity in gene expression, regulation, and coherence in the frontal cortex and hippocampus across development and schizophrenia

L Collado-Torres, EE Burke, A Peterson, JH Shin… - Neuron, 2019 - cell.com
… 245 differentially expressed genes (DEGs) associated with schizophrenia within the …
Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia

Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex

KR Maynard, L Collado-Torres, LM Weber… - Nature …, 2021 - nature.com
… of genes associated with schizophreniabrain cytoarchitecture of postmortem human brain
tissue would substantially advance our understanding of studies of human brain development

[HTML][HTML] Whole-genome and RNA sequencing reveal variation and transcriptomic coordination in the developing human prefrontal cortex

DM Werling, S Pochareddy, J Choi, JY An, B Sheppard… - Cell reports, 2020 - cell.com
… the transitional genes enriched for cell-type-specific genes and neuropsychiatric risk loci,
underscoring the importance of cataloging developmental trajectories in understanding cortical

Analysis of the caudate nucleus transcriptome in individuals with schizophrenia highlights effects of antipsychotics and new risk genes

KJM Benjamin, Q Chen, AE Jaffe, JM Stolz… - Nature …, 2022 - nature.com
… To illuminate the regional specificity of caudate eQTLs, we next asked about the proportion
… We further speculate that the development of drugs targeting select presynaptic components …

Sex-specific differences in the transcriptome of the human dorsolateral prefrontal cortex in schizophrenia

Z Yu, K Ueno, R Funayama, M Sakai, N Nariai… - Molecular …, 2023 - Springer
… , such as aberrant neurodevelopment in schizophrenia. The developmental and genetic
regulation of the human cortex transcriptome may elucidate schizophrenic pathogenesis [7]. The …

Gene expression and epigenetic regulation in the prefrontal cortex of schizophrenia

W Bilecki, M Maćkowiak - Genes, 2023 - mdpi.com
… and transcriptome sequencing, showed alterations in gene … besides genetics are involved
in schizophrenia development [… factors for the development of schizophrenia in later life …

Sex differences in the human brain transcriptome of cases with schizophrenia

GE Hoffman, Y Ma, KS Montgomery, J Bendl… - Biological …, 2022 - Elsevier
… two cohorts and involved a number of diverse pathways, including neural nucleus development,
neuron projection morphogenesis, and regulation of neural precursor cell proliferation. …

[HTML][HTML] Genetic control of expression and splicing in developing human brain informs disease mechanisms

RL Walker, G Ramaswami, C Hartl, N Mancuso… - Cell, 2019 - cell.com
brain development is a critical epoch for neuropsychiatric disease susceptibility, we characterized
the genetic control of the transcriptome … -specific mechanisms in schizophrenia (SCZ). …