Cortical cellular diversity and development in schizophrenia
… development are governed by the transcriptome and epigenome, two levels of gene regulation
that have the potential to reflect both genetic … direction for illuminating genome regulation …
that have the potential to reflect both genetic … direction for illuminating genome regulation …
Cortical gene expression architecture links healthy neurodevelopment to the imaging, transcriptomics and genetics of autism and schizophrenia
…, Lifespan Brain Chart Consortium… - Nature …, 2024 - nature.com
… Leveraging independent RNA-seq datasets on single-cell and developmental gene
expression, we further demonstrate that all three components are generalizable to other datasets, …
expression, we further demonstrate that all three components are generalizable to other datasets, …
Regional heterogeneity in gene expression, regulation, and coherence in the frontal cortex and hippocampus across development and schizophrenia
L Collado-Torres, EE Burke, A Peterson, JH Shin… - Neuron, 2019 - cell.com
… 245 differentially expressed genes (DEGs) associated with schizophrenia within the …
Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia …
Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia …
Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex
… of genes associated with schizophrenia … brain cytoarchitecture of postmortem human brain
tissue would substantially advance our understanding of studies of human brain development …
tissue would substantially advance our understanding of studies of human brain development …
[HTML][HTML] Whole-genome and RNA sequencing reveal variation and transcriptomic coordination in the developing human prefrontal cortex
… the transitional genes enriched for cell-type-specific genes and neuropsychiatric risk loci,
underscoring the importance of cataloging developmental trajectories in understanding cortical …
underscoring the importance of cataloging developmental trajectories in understanding cortical …
Analysis of the caudate nucleus transcriptome in individuals with schizophrenia highlights effects of antipsychotics and new risk genes
… To illuminate the regional specificity of caudate eQTLs, we next asked about the proportion
… We further speculate that the development of drugs targeting select presynaptic components …
… We further speculate that the development of drugs targeting select presynaptic components …
Sex-specific differences in the transcriptome of the human dorsolateral prefrontal cortex in schizophrenia
… , such as aberrant neurodevelopment in schizophrenia. The developmental and genetic
regulation of the human cortex transcriptome may elucidate schizophrenic pathogenesis [7]. The …
regulation of the human cortex transcriptome may elucidate schizophrenic pathogenesis [7]. The …
Gene expression and epigenetic regulation in the prefrontal cortex of schizophrenia
W Bilecki, M Maćkowiak - Genes, 2023 - mdpi.com
… and transcriptome sequencing, showed alterations in gene … besides genetics are involved
in schizophrenia development [… factors for the development of schizophrenia in later life …
in schizophrenia development [… factors for the development of schizophrenia in later life …
Sex differences in the human brain transcriptome of cases with schizophrenia
… two cohorts and involved a number of diverse pathways, including neural nucleus development,
neuron projection morphogenesis, and regulation of neural precursor cell proliferation. …
neuron projection morphogenesis, and regulation of neural precursor cell proliferation. …
[HTML][HTML] Genetic control of expression and splicing in developing human brain informs disease mechanisms
… brain development is a critical epoch for neuropsychiatric disease susceptibility, we characterized
the genetic control of the transcriptome … -specific mechanisms in schizophrenia (SCZ). …
the genetic control of the transcriptome … -specific mechanisms in schizophrenia (SCZ). …