… Developmental pharmacology describes the impact of maturation on drug disposition (pharmacokinetics,
PK) and drug effects (pharmacodynamics, PD) throughout the paediatric age …

… It also permits exploration of the impact of different covariates such as age, weight, disease
characteristics, or comedication to explain the variability in medicine disposition or effects. …

… , to respond to medications in children compared with adults. In this chapter we discuss
basic pharmacologic principles as they relate to drugs commonly used by anesthesiologists. …

… quantifying proteins implicated in drug disposition, and in silico … of childhood development
on drug disposition, particularly … of drug disposition pathways for which developmental trends …

… Acquiring knowledge on drug disposition and action in infant is challenging because of the
problem of sparse and unbalanced data obtained for each individual infant due to the limited …

… There are well-established physiological differences between neonates and infants compared
with older children who have the potential to significantly impact on drug disposition, and …

… of total body surface area to body mass in infants exceeds that in adults), and maturation
of … in drug disposition. The rate and extent of drug absorption depends on developmental …

… of drug disposition and metabolism in preterm neonates. We highlight the challenges in
pharmacometrics studies on hepatic drug … gestational age and a newborn child born at 28 weeks …

… of drug disposition and creation of age-appropriate dosing guidelines. We present innovative
approaches to study these developmental changes in relation to drug metabolism and …

… An extensive and contemporary description of the maturational covariates of the developmental
pharmacology is beyond the scope of this review and it is available elsewhere (10, 11, …