… Xenobiotic chemicals can be hydrophilic or lipophilic. Hydrophilic chemicals are less absorbed
and more easily excreted … substrate selectivity are very different between FMOs and CYPs…

… differences between species in maturation before and after birth. Absorption, distribution,
metabolism, and excretion … and maturation, which will lead to differences in toxicity and efficacy. …

… , distribution, excretion, … differences in the biotransformation of xenobiotics in lower
vertebrates (except a few fish species) and invertebrates, although this is a common finding among …

… the elimination of xenobiotic agents. In this review, we describe the different systems related
to the detoxification of xenobiotics in … The exit of different xenobiotics from the CNS generally …

… host absorption and xenobiotic metabolism. Image 1 … to differences in drug metabolism
between individuals and … or endobiotics with small molecules to alter their excretion. The most …

… in more uptake of xenobiotics because of the difference in … to excrete xenobiotics, although
no apparent research has been done to address this. Similarly, transfer of xenobiotics from …

… xenobiotic metabolism (in this chapter, the terms “xenobiotic … elimination and is the topic
of the remainder of this chapter. … and differences in drug bioavailability, even between …

… to a xenobiotic or to a metabolite of phase I metabolism. The … are responsible for the uptake
and excretion of various … The differences in the expression levels of 12 miRNAs between …

… of absorption, distribution, metabolism, and excretion (ADME… absortion, metabolism and
cellular excretion of xenobiotics, … shared among the same enzyme family and between different …

… xenobiotic metabolites are further metabolized and excreted … specific xenobiotics but rather
that metabolism arises from … - and species-level variations in xenobiotic metabolism. When …