… cells that are resistant to bortezomib or carfilzomib. We hypothesized that by inhibiting P-glycoprotein
multiple myeloma cell sensitivity to proteasome inhibitors … Differential expression …

… We also found that MUM24 cells treated with bortezomib and … oleandrin-dependent CRT
expression in breast cancer cells [19]. … (A) Clustering of differential genes from DNA microarray …

… proteasome inhibitor bortezomib. Similarly, the combination of trametinib and bortezomib,
rather than single-drug treatment, … was used for differential analysis to evaluate the genes that …

… We examined proteasome activity in CTR-KD versus ISG-KD ARD cells. PI exposure
resulted in greater proteasome inhibition in ISG-KD cells than in CTR-KD cells (Figure 4A); …

… , MM cells are hypersensitive to proteasome inhibition [4]. By inhibiting the proteasome …
lines (Table 1) and MM patients (Figure 7) likely because they possess intrinsic differential …

… cancers, including carcinoma of colon 10 , breast cancer 11 , … Proteasome inhibition prevents
the clearance of large … MM cells contain greater proportions of less-differentiated cells, and …

… inhibitors with Bortezomib, a proteasome inhibitor, displayed particularly strong inhibition
of MDA-MB-231 cells … differential gene expression analysis to identify genes that were 2-fold …

… IAPs have become attractive molecular targets for cancer treatment. Here, … differential
antiproliferation effects in TNBC cells. We next assessed whether birinapant has a synergistic effect …

… inhibitors (Fig. 4BC, Suppl. Figure 6AC). The same was true for the proteasome; although the
expression of many proteasome … towards proteasome inhibitors MG132 and bortezomib did …

… molecular mechanisms by analyzing the differential gene … than bortezomib, which is one
of the most potent inhibitors of … proteasome inhibition activity might also be affecting cellular …