[HTML][HTML] Mechanisms underlying reversed TRAIL sensitivity in acquired bortezomib-resistant non-small cell lung cancer cells
L De Wilt, BK Sobocki, G Jansen, H Tabeian… - Cancer Drug …, 2024 - ncbi.nlm.nih.gov
… has been examined, including bortezomib (BTZ). BTZ is a prototype proteasome inhibitor
that primarily targets the β5 subunit of the proteasome, thereby inhibiting the degradation of …
that primarily targets the β5 subunit of the proteasome, thereby inhibiting the degradation of …
[HTML][HTML] Natural agents as novel potential source of proteasome inhibitors with anti-tumor activity: focus on multiple myeloma
FA Ambrosio, G Costa, ME Gallo Cantafio, R Torcasio… - Molecules, 2023 - mdpi.com
… by the proliferation of terminally differentiated antibody-producing plasma cells (PCs) [1,2]. …
bortezomib-induced proteasome inhibition and ER stress, and subsequent tumor cell death …
bortezomib-induced proteasome inhibition and ER stress, and subsequent tumor cell death …
Carfilzomib treatment causes molecular and functional alterations of human induced pluripotent stem cell–derived cardiomyocytes
… Cardiotoxicity following treatment with proteasome inhibitors … differentiated toward
cardiomyocytes using small molecules or … reported that proteasome inhibitors such as bortezomib …
cardiomyocytes using small molecules or … reported that proteasome inhibitors such as bortezomib …
Opposing effects of metformin mediated mTORC1 inhibition on IRES possessing anti-apoptotic proteins in breast cancer cell lines
Z Jahani, J Davoodi - Biochemical and Biophysical Research …, 2022 - Elsevier
… Interestingly, a shorter treatment time of 8 h, however, was accompanied by … proteasome
inhibitor, Bortezomib, caused the upregulation of the tested anti-apoptotic proteins in both cell …
inhibitor, Bortezomib, caused the upregulation of the tested anti-apoptotic proteins in both cell …
[HTML][HTML] Novel carfilzomib-based combinations as potential therapeutic strategies for liposarcomas
… Proteasome inhibitors, such as bortezomib and carfilzomib, … proteomic landscape after
proteasome inhibition. Based on … treatments, and the differential expression became significant …
proteasome inhibition. Based on … treatments, and the differential expression became significant …
Proteasome inhibitors trigger mutations via activation of caspases and CAD, but mutagenesis provoked by the HDAC inhibitors vorinostat and romidepsin is caspase …
… cells. DNA damage and mutations were also detected in cells treated with the proteasome
inhibitor bortezomib… classes stimulated caspase activation consistent with apoptotic cell death. …
inhibitor bortezomib… classes stimulated caspase activation consistent with apoptotic cell death. …
Anti-Cancer Agents Work in Antagonism with Inhibitors of HSP 72
MM Sahib, P Marsico, JHH Williams - Diseases & Research, 2023 - dr.clintile.com
… , may reflect differential … effect of HSP inhibitors and proteasome inhibitors[36]. Similar study
reporting inhibition of heat shock factor -1 has improved treatment efficiency of Bortezomib in …
reporting inhibition of heat shock factor -1 has improved treatment efficiency of Bortezomib in …
[HTML][HTML] Clonal heterogeneity in ER+ breast cancer reveals the proteasome and PKC as potential therapeutic targets
L Beumers, EI Vlachavas, S Borgoni… - … Breast Cancer, 2023 - nature.com
… on the proteasome. Accordingly, we utilized the proteasome inhibitor Bortezomib which is
applied … Finally, differential expression analysis between the different cell lines and clones was …
applied … Finally, differential expression analysis between the different cell lines and clones was …
Bortezomib-induced aerobic glycolysis contributes to chemotherapy-induced painful peripheral neuropathy
T Ludman, OK Melemedjian - Molecular pain, 2019 - journals.sagepub.com
… Using extracellular flux analysis, this study demonstrated that the proteasome inhibitor,
bortezomib, enhanced glycolysis while suppressing oxidative phosphorylation in the sensory …
bortezomib, enhanced glycolysis while suppressing oxidative phosphorylation in the sensory …
[HTML][HTML] Proteasomal cysteine deubiquitinase inhibitor b-AP15 suppresses migration and induces apoptosis in diffuse large B cell lymphoma
L Jiang, Y Sun, J Wang, Q He, X Chen, X Lan… - … & Clinical Cancer …, 2019 - Springer
… However, the molecular basis for these differential responses … 20S proteasome inhibitor
bortezomib, which was approved … the toxicity and limitation of bortezomib have been observed […
bortezomib, which was approved … the toxicity and limitation of bortezomib have been observed […