[HTML][HTML] Mechanisms underlying reversed TRAIL sensitivity in acquired bortezomib-resistant non-small cell lung cancer cells

L De Wilt, BK Sobocki, G Jansen, H Tabeian… - Cancer Drug …, 2024 - ncbi.nlm.nih.gov
… has been examined, including bortezomib (BTZ). BTZ is a prototype proteasome inhibitor
that primarily targets the β5 subunit of the proteasome, thereby inhibiting the degradation of …

[HTML][HTML] Natural agents as novel potential source of proteasome inhibitors with anti-tumor activity: focus on multiple myeloma

FA Ambrosio, G Costa, ME Gallo Cantafio, R Torcasio… - Molecules, 2023 - mdpi.com
… by the proliferation of terminally differentiated antibody-producing plasma cells (PCs) [1,2]. …
bortezomib-induced proteasome inhibition and ER stress, and subsequent tumor cell death …

Carfilzomib treatment causes molecular and functional alterations of human induced pluripotent stem cell–derived cardiomyocytes

P Forghani, A Rashid, F Sun, R Liu, D Li… - Journal of the …, 2021 - Am Heart Assoc
… Cardiotoxicity following treatment with proteasome inhibitorsdifferentiated toward
cardiomyocytes using small molecules or … reported that proteasome inhibitors such as bortezomib

Opposing effects of metformin mediated mTORC1 inhibition on IRES possessing anti-apoptotic proteins in breast cancer cell lines

Z Jahani, J Davoodi - Biochemical and Biophysical Research …, 2022 - Elsevier
… Interestingly, a shorter treatment time of 8 h, however, was accompanied by … proteasome
inhibitor, Bortezomib, caused the upregulation of the tested anti-apoptotic proteins in both cell

[HTML][HTML] Novel carfilzomib-based combinations as potential therapeutic strategies for liposarcomas

M Jeitany, A Prabhu, P Dakle, E Pathak… - Cellular and Molecular …, 2021 - Springer
Proteasome inhibitors, such as bortezomib and carfilzomib, … proteomic landscape after
proteasome inhibition. Based on … treatments, and the differential expression became significant …

Proteasome inhibitors trigger mutations via activation of caspases and CAD, but mutagenesis provoked by the HDAC inhibitors vorinostat and romidepsin is caspase …

MA Miles, MA Harris, CJ Hawkins - Apoptosis, 2019 - Springer
cells. DNA damage and mutations were also detected in cells treated with the proteasome
inhibitor bortezomib… classes stimulated caspase activation consistent with apoptotic cell death. …

Anti-Cancer Agents Work in Antagonism with Inhibitors of HSP 72

MM Sahib, P Marsico, JHH Williams - Diseases & Research, 2023 - dr.clintile.com
… , may reflect differentialeffect of HSP inhibitors and proteasome inhibitors[36]. Similar study
reporting inhibition of heat shock factor -1 has improved treatment efficiency of Bortezomib in …

[HTML][HTML] Clonal heterogeneity in ER+ breast cancer reveals the proteasome and PKC as potential therapeutic targets

L Beumers, EI Vlachavas, S Borgoni… - … Breast Cancer, 2023 - nature.com
… on the proteasome. Accordingly, we utilized the proteasome inhibitor Bortezomib which is
applied … Finally, differential expression analysis between the different cell lines and clones was …

Bortezomib-induced aerobic glycolysis contributes to chemotherapy-induced painful peripheral neuropathy

T Ludman, OK Melemedjian - Molecular pain, 2019 - journals.sagepub.com
… Using extracellular flux analysis, this study demonstrated that the proteasome inhibitor,
bortezomib, enhanced glycolysis while suppressing oxidative phosphorylation in the sensory …

[HTML][HTML] Proteasomal cysteine deubiquitinase inhibitor b-AP15 suppresses migration and induces apoptosis in diffuse large B cell lymphoma

L Jiang, Y Sun, J Wang, Q He, X Chen, X Lan… - … & Clinical Cancer …, 2019 - Springer
… However, the molecular basis for these differential responses … 20S proteasome inhibitor
bortezomib, which was approved … the toxicity and limitation of bortezomib have been observed […