Generation of TRAIL-resistant cell line models reveals distinct adaptive mechanisms for acquired resistance and re-sensitization

A Cingöz, E Ozyerli-Goknar, T Morova, F Seker-Polat… - Oncogene, 2021 - nature.com
proteasome inhibitor, Bortezomib, all resistant subpopulations were re-sensitized to TRAIL.
While the cells continued to survive under Bortezomib … ), suggesting differential routes of …

An impaired ubiquitin-proteasome system increases APOBEC3A abundance

…, J Meekma, MI Savenkova, D Ng, CA Osbron… - … cancer, 2023 - academic.oup.com
… the ubiquitin-proteasome system with proteasome inhibitors, including … Therapeutic proteasome
inhibitors bortezomib, carfilzomib … Differential expressed loci were defined using HOMER …

Inhibitory effort of MLN2238 on basal-like breast cancer: An investigation based on the gene set enrichment analysis

D Wang, Y Li, F Luo, X Song, S Wu… - … and Molecular …, 2023 - mail.cellmolbiol.org
… -generation reversible proteasome inhibitors with a similar efficacy to bortezomib, and has
… ; (C) TCGA database analysis of the relatively differential expression level (log2) of PLK1 in …

Proteasomal inhibition triggers viral oncoprotein degradation via autophagy-lysosomal pathway

C Gain, S Malik, S Bhattacharjee, A Ghosh… - PLoS …, 2020 - journals.plos.org
… previously demonstrated experiment with bortezomib [52], … Differential gene expressions
were performed based on p-… in response to proteasomal inhibition in breast cancer cell lines [37]…

Early recovery of proteasome activity in cells pulse-treated with proteasome inhibitors is independent of DDI2

I Ibtisam, AF Kisselev - Elife, 2024 - elifesciences.org
breast cancer cell lines, SUM149 and MDA-MB-231 (Figure 1e). Proteasome activity in these
cells … were treated for 1 hr at indicated concentrations of bortezomib (Btz) and carfilzomib (…

[PDF][PDF] Exploiting autophagy in multiple myeloma

M Ho, A Patel, C Hanley, A Murphy… - J Cancer Metastasis …, 2019 - researchgate.net
cellular ATP levels to ensure survival in differentiated plasma … the transcriptional program of
human breast tumors. Proc Natl … to the proteasome inhibitor bortezomib is correlated with the …

… (TRPV1) promotes terminal mitophagy in multiple myeloma, disturbing calcium homeostasis and targeting ubiquitin pathway and bortezomib-induced unfolded protein …

K Beider, E Rosenberg… - Journal of Hematology & …, 2020 - Springer
… Furthermore, our data point out the differential effect of … induced by proteasome inhibitors
bortezomib and carfilzomib. This … between proteasome inhibitors and AMG9810 in MM cells. …

TOP2A expression predicts responsiveness to carfilzomib in myeloma and informs novel combinatorial strategies for enhanced proteasome inhibitor cell killing

A Reale, T Khong, S Mithraprabhu… - Leukemia & …, 2021 - Taylor & Francis
… , the proteasome inhibitor (PI) bortezomib (BRZ) represented a major breakthrough in MM
treatment in … Differential expression of probes between the sensitive and resistant HMCLs was …

[HTML][HTML] Inhibition of the ʟ-glutamine transporter ASCT2 sensitizes plasma cell myeloma cells to proteasome inhibitors

MK Prelowska, D Mehlich, MT Ugurlu, H Kedzierska… - Cancer Letters, 2021 - Elsevier
… PCM cells are particularly vulnerable to the ER stress inducing agents, such as proteasome
inhibitors (PIs, bortezomib… This has been confirmed by reports showing that, in breast cancer

[HTML][HTML] Diagnostic and therapeutic potential of protease inhibition

N Ćwilichowska, KW Świderska, A Dobrzyń… - Molecular Aspects of …, 2022 - Elsevier
… In in vivo studies on mice bearing human breast cancer cells (MDA-MB-… differentiated
between cancer and healthy cells. At the molecular level, BMV109 was found in mononuclear cells, …