Natural agents as novel potential source of proteasome inhibitors with anti-tumor activity: focus on multiple myeloma

FA Ambrosio, G Costa, ME Gallo Cantafio, R Torcasio… - Molecules, 2023 - mdpi.com
… by the proliferation of terminally differentiated antibody-producing plasma cells (PCs) [1,2]. …
bortezomib-induced proteasome inhibition and ER stress, and subsequent tumor cell death …

The effects of proteasome inhibitors on telomerase activity and regulation in multiple myeloma cells

N Shalem-Cohavi, E Beery, J Nordenberg… - … Journal of Molecular …, 2019 - mdpi.com
… its potential effect on telomerase activity (TA) in MM cells. … proteasome inhibitor bortezomib
(Brt) inhibits TA in MM cells by … a differential ability of both drugs to inhibit proliferation and …

MicroRNAs as possible indicators of drug sensitivity in breast cancer cell lines

K Uhr, WJC Prager-van der Smissen, AAJ Heine… - PLoS …, 2019 - journals.plos.org
… In the analysis we combined the data of 36 cell lines for which 34 drugs gave differential
Drug sensitivity to the proteasome inhibitor Bortezomib [53] was associated with hsa-let-7a-5p …

Isoginkgetin, a natural biflavonoid proteasome inhibitor, sensitizes cancer cells to apoptosis via disruption of lysosomal homeostasis and impaired protein clearance

J Tsalikis, M Abdel-Nour, A Farahvash… - Molecular and …, 2019 - Taylor & Francis
… the clinically approved proteasome inhibitor bortezomib. We … MDA-MD-468 breast cancer
cells, treated with either DMSO … Differentiated plasma cells are hypersecretory and thus rely …

… of the unfolded protein response, modulation of protein synthesis, DNA damage, lysosomal impairment, and potentiation of toxicity caused by proteasome inhibition

MR Subeha, AA Goyeneche, P Bustamante, MA Lisio… - Cancers, 2021 - mdpi.com
… caused by the proteasome inhibitor bortezomib. Overall, our … target HGSOC cells of differential
platinum sensitivities via … breast cancer and castration-resistant prostate cancer [14,64]…

Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression

S Banerjee, T Wei, J Wang, JJ Lee… - Proceedings of the …, 2019 - National Acad Sciences
… the shortcomings of current proteasome inhibitors, we need … for TNBC treatment, we examined
the differential expression … To test this, we used bortezomib-resistant cell lines that were …

Evidencing a pancreatic ductal adenocarcinoma subpopulation sensitive to the proteasome inhibitor carfilzomib

NA Fraunhoffer, AM Abuelafia, M Bigonnet… - Clinical Cancer …, 2020 - AACR
… mainly in myeloma and breast cancer. These studies reported that the … , bortezomib, and
ixazomib) to analyze their differential … of the proteasome inhibitors carfilzomib, bortezomib, and …

The proteasome inhibitor, bortezomib, induces prostate cancer cell death by suppressing the expression of prostate-specific membrane antigen, as well as androgen …

K Kuroda, H Liu - International Journal of Oncology, 2019 - spandidos-publications.com
… the growth of PC cells. The proteasome inhibitor, BZ, has the same inhibitory effect on the …
Our results from cells transfected with AR DNA or PSMA DNA would also be more relevant …

Opposing effects of metformin mediated mTORC1 inhibition on IRES possessing anti-apoptotic proteins in breast cancer cell lines

Z Jahani, J Davoodi - Biochemical and Biophysical Research …, 2022 - Elsevier
… Interestingly, a shorter treatment time of 8 h, however, was accompanied by … proteasome
inhibitor, Bortezomib, caused the upregulation of the tested anti-apoptotic proteins in both cell

Evaluation of the NRF1-proteasome axis as a therapeutic target in breast cancer

HA Byers, AN Brooks, JR Vangala, JM Grible… - Scientific Reports, 2023 - nature.com
… vulnerable breast cancer subtype to proteasome inhibition … sensitivity to the proteasome
inhibitors bortezomib, carfilzomib, … Differential expression between breast cancer and normal …