Connectivity map-based drug repositioning of bortezomib to reverse the metastatic effect of GALNT14 in lung cancer

OS Kwon, H Lee, HJ Kong, EJ Kwon, JE Park, W Lee… - Oncogene, 2020 - nature.com
… , and the multidrug resistance of breast cancer cells [25]. … survival (RFS) and differential
expression analyses. The expression … this effect was the direct result of proteasome inhibition. To …

[HTML][HTML] The landscape of signaling pathways and proteasome inhibitors combinations in multiple myeloma

T Paradzik, C Bandini, E Mereu, M Labrador, E Taiana… - Cancers, 2021 - mdpi.com
… ) is a cancer of terminally differentiated plasma cells and represents … proteasome inhibitors,
Zhu at al. identified 37 genes that enhance bortezomib activity in the multiple myeloma cells

[HTML][HTML] Clonal heterogeneity in ER+ breast cancer reveals the proteasome and PKC as potential therapeutic targets

L Beumers, EI Vlachavas, S Borgoni… - … Breast Cancer, 2023 - nature.com
… on the proteasome. Accordingly, we utilized the proteasome inhibitor Bortezomib which is
applied … Finally, differential expression analysis between the different cell lines and clones was …

[HTML][HTML] Optimization of cell viability assays to improve replicability and reproducibility of cancer drug sensitivity screens

P Larsson, H Engqvist, J Biermann… - Scientific reports, 2020 - nature.com
… of confounders on cell viability for MCF7 and HCC38 breast cancer cell lines … and a
proteasome inhibitor (bortezomib). Variance component analysis demonstrated that variations in cell

Proteasome inhibition in multiple myeloma: lessons for other cancers

P Saavedra-García, F Martini… - … of Physiology-Cell …, 2020 - journals.physiology.org
… plasma cells, the terminally differentiated effector cells of … bortezomib downregulates HK2
expression in MM cells provides evidence for a functional link between proteasome inhibition

[HTML][HTML] Two Novel Precursors of the HIV-1 Protease Inhibitor Darunavir Target the UPR/Proteasome System in Human Hepatocellular Carcinoma Cell Line HepG2

R Rinaldi, R Miglionico, I Nigro, R D'Orsi… - Cells, 2021 - mdpi.com
… -approved proteasome inhibitors (bortezomib, carfilzomib, … differentiated cell lines HepG2
and HuH7 than for JHH6, as already reported in the literature for another proteasome inhibitor […

[HTML][HTML] H727 cells are inherently resistant to the proteasome inhibitor carfilzomib, yet require proteasome activity for cell survival and growth

MJ Lee, Z Miller, JE Park, D Bhattarai, W Lee… - Scientific reports, 2019 - nature.com
… success of the FDA approved proteasome inhibitors (PIs) bortezomib (Velcade, Btz), carfilzomib
… Based on the differential expression pattern of proteasome catalytic subunits in H727 as …

MiR-383 sensitizes osteosarcoma cells to bortezomib treatment via down-regulating PSMB5

H Wang, C Bai, X Dang, H Wang - Molecular Biology Reports, 2024 - Springer
Bortezomib (Velcade), a proteasome inhibitorproteasome subunits expression in bortezomib
efficiency, we investigated whether OS cells display differential sensitivities to bortezomib

Bortezomib Stabilizes and Activates p53 in Proliferative Compartments of Both Normal and Tumor Tissues In Vivo

Y Xue, N Barker, S Hoon, P He, T Thakur, SR Abdeen… - Cancer Research, 2019 - AACR
… p53 protein stabilized via proteasome inhibition to perform similar … Treating mice with the
proteasome inhibitor bortezomib … : differentiated cells in the villi, rapidly proliferating cells in the …

The proteasome inhibitor bortezomib induces tongue, pharynx and salivary gland cancer cells death in vitro and delays tumor growth of salivary gland cancer cells …

M Benvenuto, S Ciuffa, C Focaccetti, D Sbardella… - 2021 - researchsquare.com
… Our ndings further support the use of Bortezomib for the treatmentDifferential bortezomib
sensitivity in head and neck cancer lines … in human mesothelioma and breast cancer cell lines. …