Connectivity map-based drug repositioning of bortezomib to reverse the metastatic effect of GALNT14 in lung cancer
… , and the multidrug resistance of breast cancer cells [25]. … survival (RFS) and differential
expression analyses. The expression … this effect was the direct result of proteasome inhibition. To …
expression analyses. The expression … this effect was the direct result of proteasome inhibition. To …
[HTML][HTML] The landscape of signaling pathways and proteasome inhibitors combinations in multiple myeloma
T Paradzik, C Bandini, E Mereu, M Labrador, E Taiana… - Cancers, 2021 - mdpi.com
… ) is a cancer of terminally differentiated plasma cells and represents … proteasome inhibitors,
Zhu at al. identified 37 genes that enhance bortezomib activity in the multiple myeloma cells …
Zhu at al. identified 37 genes that enhance bortezomib activity in the multiple myeloma cells …
[HTML][HTML] Clonal heterogeneity in ER+ breast cancer reveals the proteasome and PKC as potential therapeutic targets
L Beumers, EI Vlachavas, S Borgoni… - … Breast Cancer, 2023 - nature.com
… on the proteasome. Accordingly, we utilized the proteasome inhibitor Bortezomib which is
applied … Finally, differential expression analysis between the different cell lines and clones was …
applied … Finally, differential expression analysis between the different cell lines and clones was …
[HTML][HTML] Optimization of cell viability assays to improve replicability and reproducibility of cancer drug sensitivity screens
… of confounders on cell viability for MCF7 and HCC38 breast cancer cell lines … and a
proteasome inhibitor (bortezomib). Variance component analysis demonstrated that variations in cell …
proteasome inhibitor (bortezomib). Variance component analysis demonstrated that variations in cell …
Proteasome inhibition in multiple myeloma: lessons for other cancers
P Saavedra-García, F Martini… - … of Physiology-Cell …, 2020 - journals.physiology.org
… plasma cells, the terminally differentiated effector cells of … bortezomib downregulates HK2
expression in MM cells provides evidence for a functional link between proteasome inhibition …
expression in MM cells provides evidence for a functional link between proteasome inhibition …
[HTML][HTML] Two Novel Precursors of the HIV-1 Protease Inhibitor Darunavir Target the UPR/Proteasome System in Human Hepatocellular Carcinoma Cell Line HepG2
R Rinaldi, R Miglionico, I Nigro, R D'Orsi… - Cells, 2021 - mdpi.com
… -approved proteasome inhibitors (bortezomib, carfilzomib, … differentiated cell lines HepG2
and HuH7 than for JHH6, as already reported in the literature for another proteasome inhibitor […
and HuH7 than for JHH6, as already reported in the literature for another proteasome inhibitor […
[HTML][HTML] H727 cells are inherently resistant to the proteasome inhibitor carfilzomib, yet require proteasome activity for cell survival and growth
… success of the FDA approved proteasome inhibitors (PIs) bortezomib (Velcade, Btz), carfilzomib
… Based on the differential expression pattern of proteasome catalytic subunits in H727 as …
… Based on the differential expression pattern of proteasome catalytic subunits in H727 as …
MiR-383 sensitizes osteosarcoma cells to bortezomib treatment via down-regulating PSMB5
H Wang, C Bai, X Dang, H Wang - Molecular Biology Reports, 2024 - Springer
… Bortezomib (Velcade), a proteasome inhibitor … proteasome subunits expression in bortezomib
efficiency, we investigated whether OS cells display differential sensitivities to bortezomib …
efficiency, we investigated whether OS cells display differential sensitivities to bortezomib …
Bortezomib Stabilizes and Activates p53 in Proliferative Compartments of Both Normal and Tumor Tissues In Vivo
… p53 protein stabilized via proteasome inhibition to perform similar … Treating mice with the
proteasome inhibitor bortezomib … : differentiated cells in the villi, rapidly proliferating cells in the …
proteasome inhibitor bortezomib … : differentiated cells in the villi, rapidly proliferating cells in the …
The proteasome inhibitor bortezomib induces tongue, pharynx and salivary gland cancer cells death in vitro and delays tumor growth of salivary gland cancer cells …
M Benvenuto, S Ciuffa, C Focaccetti, D Sbardella… - 2021 - researchsquare.com
… Our ndings further support the use of Bortezomib for the treatment … Differential bortezomib
sensitivity in head and neck cancer lines … in human mesothelioma and breast cancer cell lines. …
sensitivity in head and neck cancer lines … in human mesothelioma and breast cancer cell lines. …