Chemotherapeutic effect of SR9009, a REV-ERB agonist, on the human glioblastoma T98G cells
PM Wagner, NM Monjes, ME Guido - ASN neuro, 2019 - journals.sagepub.com
… Here, we investigated SR9009 effects on T98G cell viability, differential … it with the proteasome
inhibitor Bortezomib treatment. SR9009-treated cells exhibited significant reduction in cell …
inhibitor Bortezomib treatment. SR9009-treated cells exhibited significant reduction in cell …
The proteasome as a target for cancer therapy
P Larsson - 2023 - gupea.ub.gu.se
… breast cancer chemotherapy and proteasome inhibitors) used as … eg, bortezomib and
cisplatin (as single) or eg, bortezomib+… Differential expression of DNAJB1 and HMOX1 (geometric …
cisplatin (as single) or eg, bortezomib+… Differential expression of DNAJB1 and HMOX1 (geometric …
[HTML][HTML] Novel carfilzomib-based combinations as potential therapeutic strategies for liposarcomas
… Proteasome inhibitors, such as bortezomib and carfilzomib, … proteomic landscape after
proteasome inhibition. Based on … treatments, and the differential expression became significant …
proteasome inhibition. Based on … treatments, and the differential expression became significant …
Bortezomib potentiates the antitumor effect of tributyltin (IV) ferulate in colon cancer cells exacerbating ER stress and promoting apoptosis
A Celesia, T Fiore, D Di Liberto, M Giuliano… - Inorganica Chimica …, 2022 - Elsevier
… the proteasome inhibitor bortezomib, since it represents a widely documented apoptotic inducer
in tumor cells [… only modest effects on the viability of differentiated Caco-2 cells that were …
in tumor cells [… only modest effects on the viability of differentiated Caco-2 cells that were …
M3258 is a selective inhibitor of the immunoproteasome subunit LMP7 (β5i) delivering efficacy in multiple myeloma models
MP Sanderson, M Friese-Hamim… - Molecular Cancer …, 2021 - AACR
… myeloma and mantle cell lymphoma xenograft models compared with the approved nonselective
proteasome inhibitors bortezomib and ixazomib. The differentiated preclinical profile of …
proteasome inhibitors bortezomib and ixazomib. The differentiated preclinical profile of …
Mitochondrial metabolism promotes adaptation to proteotoxic stress
… proteasome inhibitor resistance, we engineered the breast … cells in the Lo19S state to withstand
bortezomib treatment (Fig. 2b… After 3 d, we assessed differential viability (Fig. 2c). Overall, …
bortezomib treatment (Fig. 2b… After 3 d, we assessed differential viability (Fig. 2c). Overall, …
Comprehensive structure–activity relationship studies of cepafungin enabled by biocatalytic C–H oxidations
A Amatuni, A Shuster, D Abegg, A Adibekian… - ACS Central …, 2023 - ACS Publications
… cells to the clinical drug bortezomib. A preliminary series of analogues elucidated critical
determinants of potency in proteasome inhibition… for factors such as differential cell permeability, …
determinants of potency in proteasome inhibition… for factors such as differential cell permeability, …
[HTML][HTML] Evaluation of antitumoral effect of Hibiscus sabdariffa extract on human breast cancer cells
A Malacrida, J Erriquez, M Hashemi… - … and Biophysics Reports, 2022 - Elsevier
… and cells on the lower side were fixed and stained with Diff … groups, but to date only Bortezomib,
Carfilzomib and Ixazomib are … While proteasome inhibition occurs similarly in the two cell …
Carfilzomib and Ixazomib are … While proteasome inhibition occurs similarly in the two cell …
[HTML][HTML] Drug development targeting the ubiquitin–proteasome system (UPS) for the treatment of human cancers
X Zhang, S Linder, M Bazzaro - Cancers, 2020 - mdpi.com
… of the next generation of proteasome inhibitors in cancer therapies. … proteasome-associated
DUBs Breast cancer Ovarian cancer … These bortezomib-resistant cell lines displayed a cross-…
DUBs Breast cancer Ovarian cancer … These bortezomib-resistant cell lines displayed a cross-…
[HTML][HTML] BET inhibitors synergize with carfilzomib to induce cell death in cancer cells via impairing Nrf1 transcriptional activity and exacerbating the unfolded protein …
JR Vangala, A Potluri, SK Radhakrishnan - Biomolecules, 2020 - mdpi.com
… bortezomib and carfilzomib in triple-negative breast cancer … the utility of proteasome
inhibitors in treating solid tumors, we … Then, differential expression of the genes was determined …
inhibitors in treating solid tumors, we … Then, differential expression of the genes was determined …