Contributions of the heme coordinating ligands of the Pseudomonas aeruginosa outer membrane receptor HasR to extracellular heme sensing and transport

AT Dent, A Wilks - Journal of Biological Chemistry, 2020 - ASBMB
membrane receptor HasR is required for activation of the σ factor HasI and upregulation …
Differential contributions of the outer membrane receptors PhuR and HasR to heme acquisition

The role of host heme in bacterial infection

RK Donegan - Biological Chemistry, 2022 - degruyter.com
acquire host heme, the heme must transit the cellular envelope consisting of an outer
membrane (OM), a periplasmic space, and an inner … OM heme transporters PhuR and HasR. For …

Heme uptake and utilization by gram-negative bacterial pathogens

KL Richard, BR Kelley, JG Johnson - Frontiers in cellular and …, 2019 - frontiersin.org
… like HasR, many heme receptors bind free heme or heme bound … between these outer
membrane receptors with heme. In addition, … receptors and systems that enable it to acquire heme. …

Extracellular haem utilization by the opportunistic pathogen Pseudomonas aeruginosa and its role in virulence and pathogenesis

S Mouriño, A Wilks - Advances in microbial physiology, 2021 - Elsevier
… the promoter of the outer membrane haem receptor phuR that lead to … of the differential
regulation of the P. aeruginosa iron and … coli indicated HasR could acquire haem at micromolar …

Determining the Mechanism and Regulation of the Heme Assimilation System (Has) in Pseudomonas aeruginosa Heme Signaling and Acquisition

AT Dent - 2020 - search.proquest.com
… the outer membrane receptor HasR, I determined heme capture by H221 on the plug domain
of HasR is … OM heme transporter PhuR reveal heme is coordinated by Tyr-519 on the highly …

The Regulatory Role of the Cytoplasmic Heme Binding Protein PhuS in Pseudomonas aeruginosa

T Wilson - 2022 - search.proquest.com
… already acquired by the bacteria, which can be differentiated … by HasR to acquire heme,
PhuR coordinates heme through … These PBPs shuttle heme from the outer membrane receptor

How the Presence of Hemin Affects the Expression of the Different Iron Uptake Pathways in Pseudomonas aeruginosa Cells

V Normant, L Kuhn, M Munier, P Hammann… - ACS Infectious …, 2021 - ACS Publications
… different outer-membrane transporters to acquire heme from … HasS, located in the inner
membrane and spanning into the … , the heme uptake pathways involving HasR and PhuR are …

Post-transcriptional regulation of the Pseudomonas aeruginosa heme assimilation system (Has) fine-tunes extracellular heme sensing

AT Dent, S Mouriño, W Huang, A Wilks - Journal of Biological Chemistry, 2019 - ASBMB
… genes and the pyoverdine outer membrane (OM) receptor FpvA, respectively ( … Differential
contributions of the outer-membrane receptors PhuR and HasR to heme acquisition

The heme-binding protein PhuS transcriptionally regulates the Pseudomonas aeruginosa tandem sRNA prrF1, F2 locus

T Wilson, S Mouriño, A Wilks - Journal of Biological Chemistry, 2021 - ASBMB
… can acquire iron from heme via the nonredundant heme … interaction with the outer membrane
receptor HasR triggers activation … , heme transported by either the HasR or the PhuR outer

The heme-responsive PrrH sRNA regulates Pseudomonas aeruginosa pyochelin gene expression

TM Hoang, W Huang, J Gans, J Weiner, E Nowak… - Msphere, 2023 - Am Soc Microbiol
Heme acquisition is mediated by the heme assimilation (Has… to the HasR outer membrane
receptor. This, in turn, initiates a … using the extraction of differential gene expression test as …