Molecular markers of myeloid-derived suppressor cells and their functional role for homing and in disease models in mice

IN Eckert - 2023 - opus.bibliothek.uni-wuerzburg.de
bone marrow cells for 3 days followed by the activation with LPS and IFN-γ for 16 h, which
results in iNOS expression… -1 was co-expressed with CD62L and VLA-4, but not with lymph …

[HTML][HTML] CD44 engagement enhances acute myeloid leukemia cell adhesion to the bone marrow microenvironment by increasing VLA-4 avidity

JC Gutjahr, E Bayer, X Yu, JM Laufer, JP Höpner… - …, 2021 - ncbi.nlm.nih.gov
VLA-4, a CD49d/CD29 heterodimer, are important factors in progenitor cell adhesion in bone
… Notably, we did not observe CD44-VLA-4 inside-out activation in normal CD34 + mobilized …

Physiological cues involved in the regulation of adhesion mechanisms in hematopoietic stem cell fate decision

R Kulkarni, V Kale - Frontiers in Cell and Developmental Biology, 2020 - frontiersin.org
… Specifically, α4β1 (VLA-4), α5β1 (VLA-5), and αLβ2 (LFA-1) … that the CD34 + cord blood
HSCs expressing L-selectin form … the association of CXCR4 with the integrins VLA-4 and VLA-5. …

The downregulated membrane expression of CD18 in CD34+ cells defines a primitive population of human hematopoietic stem cells

C Mesa-Núñez, D Leon-Rico, M Aldea… - Stem Cell Research & …, 2020 - Springer
… of human hematopoietic stem and progenitor cells (HSPCs) from cord blood (CB), bone marrow
(BM… LFA-1 is mainly involved in the leukocyte adhesion cascade and also in the immune …

Hematopoietic multipotent progenitors and plasma cells: neighbors or roommates in the mouse bone marrow ecosystem?

A Bonaud, JP Lemos, M Espéli… - Frontiers in …, 2021 - frontiersin.org
… -biased CD34+ precursors expressing more frequently LFA-1 and L-selectin and expressing
… receptors and adhesion molecules expressed by the progenitor cells, such as VLA-4, VLA-5…

Leukocyte movement during immune responses

E Vadillo - Cell Movement in Health and Disease, 2022 - Elsevier
… the bone marrow (BM) to PB also occur. Antigen-presenting … the HEVs and employ L-selectin
to interact with CD34 and Gly-… of LFA-1 and VLA-4, resulting in firm arrest. Effector CD8 + T …

Biology of Hematopoietic Stem Cells in the Adult

R Haddad, F Pflumio… - Stem Cell Biology and …, 2022 - api.taylorfrancis.com
gene deletion in mice uncovered the contribution of VLA-4 in … of CD10 with upregulation
of L-selectin. Nat Immunol. 2012;… The chemokine SDF-1 activates the integrins LFA-1, VLA-4, …

Oncogenic deregulation of cell adhesion molecules in leukemia

R Windisch, N Pirschtat, C Kellner, L Chen-Wichmann… - Cancers, 2019 - mdpi.com
… -1 and L-selectin were diminished compared with control cells, … VLA-4-dependent adhesion
of hematopoietic progenitor cellcell adhesion molecules PSGL-1, LFA-1, CD44, and VLA-4

[HTML][HTML] Development of VLA4 and CXCR4 Antagonists for the Mobilization of Hematopoietic Stem and Progenitor Cells

PG Ruminski, MP Rettig, JF DiPersio - Biomolecules, 2024 - mdpi.com
… a sufficient number of CD34 + HSPCs from the … bone marrow microenvironment. Preclinical
and/or clinical studies have demonstrated that disrupting the interaction of CXCR4 or VLA-4

In vitro Imaging and Characterization of Hematopoietic Stem Cells on E/P Selectin Surfaces

A Rakhmatulina - 2023 - repository.kaust.edu.sa
… come into contact with the endothelial lining of the bone … α4β7, VLA-4, and LFA-1) bind
strongly to immunoglobulin cell … -1 activate the binding of CD34+ cell binding to the extracellular …