HLA-DPB1 E69 genotype and exposure in beryllium sensitisation and disease

J Crooks, MM Mroz, M VanDyke, A McGrath… - Occupational and …, 2022 - oem.bmj.com
beryllium exposure individually contribute to risk of chronic … were likely affected by differential
exposure misclassification. The … . Chronic beryllium disease and sensitization at a beryllium

[HTML][HTML] Genomic biomarkers in chronic beryllium disease and sarcoidosis

NW Lin, LA Maier, MM Mroz, S Jacobson… - Respiratory …, 2021 - Elsevier
… We hypothesized that differential expression of these genes … Both have genetic and
environmental contributions, as well as … on genetic susceptibility with HLA-DPB1 Glu 69 being the …

[HTML][HTML] Adaptive immunity in pulmonary sarcoidosis and chronic beryllium disease

SA Greaves, SM Atif, AP Fontenot - Frontiers in immunology, 2020 - frontiersin.org
… immune-mediated diseases, disease susceptibility in CBD and … many of these diseases are
similar, the differential diagnosis is … that contributes to disease development and progression. …

Lack of an exposure response and interaction with HLA-DPβ1 and DRβ1 polymorphisms in the development of beryllium toxicity in a high beryllium exposure cohort

V Widyaningsih, K Rosenman, MJ Reilly… - … of Occupational and …, 2020 - journals.lww.com
… influence the development of chronic beryllium disease (CBD) … metrics (ie, peak) and
HLA-DPB1 Glu69 and other genetic … at facility B likely contributed to the different exposure levels, …

Chronic beryllium disease: update on a moving target

MG MacMurdo, MM Mroz, DA Culver, RA Dweik… - Chest, 2020 - Elsevier
beryllium in 1971, our understanding of the risks of beryllium sensitization and chronic beryllium
disease (… in late 2018 reduced the PEL for beryllium, increased requirements for medical …

[HTML][HTML] Chronic beryllium disease (berylliosis)

LS Newman, LA Maier - Waltham (MA): UpToDate, 2021 - medilib.ir
… both beryllium exposure and HLA-DPB1 genotype contributeDIFFERENTIAL DIAGNOSIS
— The differential diagnosis of … Interestingly, the three patients with Glu69 homozygosity (…

Beryllium

N Pawlas, CM Pałczyński - Handbook on the Toxicology of Metals, 2022 - Elsevier
… measure of exposure for chronic beryllium disease (CBD). … Differential counting of the
bone marrow smears indicated a … It was found in Be-exposed individuals with the HLA-DPβ1-Glu69

Interstitial Lung Diseases of Occupational Origin

A Prasse, C Quartucci, G Zissel, G Kayser… - Orphan Lung Diseases …, 2023 - Springer
… lead to an increase of chronic beryllium disease which … role as contributing factor for
interstitial lung diseases, even … disease with a genetic background defining susceptibility and in …

Multiomic Signatures of Chronic Beryllium Disease Bronchoalveolar Lavage Cells Relate to T-Cell Function and Innate Immunity

L Li, IR Konigsberg, M Bhargava, S Liu… - American journal of …, 2022 - atsjournals.org
… Both BeS and CBD are associated with genetic variants, Glu69-containing HLA-DPB1, as …
and likely contribute to difficulty detecting signals in this population. BAL cell differentials were …

Innate and adaptive immunity in noninfectious granulomatous lung disease

AS McKee, SM Atif, MT Falta… - The Journal of …, 2022 - journals.aai.org
chronic beryllium diseasecontribution to disease (63), and several MHC class II alleles (eg,
HLA-DRB1*03:01, 04:01, 11:01, and 15:01) have been associated with disease susceptibility