Bioactive human Alzheimer brain soluble Aβ: pathophysiology and therapeutic opportunities
… In summary, descriptions of the soluble oligomeric forms of Aβ … The most bioactive Aβ
oligomers appear to be LMW, in … Fibril-containing plaques may be a major source of diffusible …
oligomers appear to be LMW, in … Fibril-containing plaques may be a major source of diffusible …
A mechanistic hypothesis for the impairment of synaptic plasticity by soluble Aβ oligomers from Alzheimer's brain
… soluble Aβ oligomers suggest that only certain bioactive forms (principally small, diffusible
oligomers… enhance clearance of existing oAβ) represents an attractive therapeutic strategy for …
oligomers… enhance clearance of existing oAβ) represents an attractive therapeutic strategy for …
Alzheimer disease pathogenesis: insights from molecular and cellular biology studies of oligomeric Aβ and tau species
XQ Chen, WC Mobley - Frontiers in Neuroscience, 2019 - frontiersin.org
… in a soluble diffusible species and that toxic species may … method for isolating biologically
active soluble Aβ-containing … methods tau oligomers appeared to constitute a minority (20%) …
active soluble Aβ-containing … methods tau oligomers appeared to constitute a minority (20%) …
Advances in targeted tracking and detection of soluble amyloid-β aggregates as a biomarker of Alzheimer's disease
… are given to soluble Aβ oligomers, due to their crucial roles in AD … with insoluble plaques,
soluble Aβ oligomers are highly … For AD, the deposition of Aβ plaques in brain represents the …
soluble Aβ oligomers are highly … For AD, the deposition of Aβ plaques in brain represents the …
Amyloid β-protein and beyond: the path forward in Alzheimer's disease
DM Walsh, DJ Selkoe - Current opinion in neurobiology, 2020 - Elsevier
… of soluble oligomers and insoluble fibers of Aβ is an … soluble, small, diffusible forms of
Aβ are the most capable of binding to plasma membranes [23,24] and conferring bioactivity…
Aβ are the most capable of binding to plasma membranes [23,24] and conferring bioactivity…
SOBA: Development and testing of a soluble oligomer binding assay for detection of amyloidogenic toxic oligomers
D Shea, E Colasurdo, A Smith… - Proceedings of the …, 2022 - National Acad Sciences
… the molecular pathology of Alzheimer’s Disease (AD). These … The toxic oligomers represent
a fraction of both the total Aβ … α–sheet containing toxic oligomers—critical early players in the …
a fraction of both the total Aβ … α–sheet containing toxic oligomers—critical early players in the …
Oligomerization and conformational change turn monomeric β-amyloid and tau proteins toxic: Their role in Alzheimer's pathogenesis
B Penke, M Szűcs, F Bogár - Molecules, 2020 - mdpi.com
… The highly toxic oligomers represent only a minority [43] of … Although the exact structure of
the highly bioactive AβO is not … , and rather the smaller, diffusible oligomers are involved in AD …
the highly bioactive AβO is not … , and rather the smaller, diffusible oligomers are involved in AD …
Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer's brain
… brain-derived bioactive 7kDa-Aβ contains a heterogeneous … dimers cross-linked at known
sites will be critical to this effort. … (7kDa-Aβ) species from water soluble extracts of Alzheimer’s …
sites will be critical to this effort. … (7kDa-Aβ) species from water soluble extracts of Alzheimer’s …
[HTML][HTML] Abundant Aβ fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer's disease brains
… Soluble oligomers of amyloid β-protein (Aβ) have been defined as aggregates in …
Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer’…
Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer’…
A rationally designed humanized antibody selective for amyloid beta oligomers in Alzheimer's disease
E Gibbs, JM Silverman, B Zhao, X Peng, J Wang… - Scientific reports, 2019 - nature.com
… insoluble aggregates from soluble monomers and oligomers … of soluble AD brain extract
gave rise to a highly reproducible … with Aβ42 representing the major aggregated (oligomeric) Aβ …
gave rise to a highly reproducible … with Aβ42 representing the major aggregated (oligomeric) Aβ …