… either chemotherapeutics for therapeutic or prosthetic groups for imaging purposes have been
… Almost all folic acid-based chemotherapeutic drugs and radiopharmaceuticals have been …

… The discovery of folic acid is the result of hard work of Lucy Wills, a medical researcher
graduating from Cambridge University with the degree of botanist and geologist. In 1930, she …

… -targeted delivery, which proved significant targeting efficacy. As a result of this strategy,
various folic acid-based small … properties weren't discovered until the middle of the 20th century. …

… We also discuss the criteria for selecting the optimal therapeutic drug payload, spacer and
… Finally, we review the folate receptor targeting SMDCs that are in preclinical development …

… A particularly promising target for selective targeting are the folate receptors (FR) that are
often over-expressed on cancer cells. Here, we report on a conjugate of the pentadentate …

Herein, we discuss the potential role of folic acid-based radiopharmaceuticals for
macrophage imaging to support clinical decision-making in patients with COVID-19. Activated …

… this receptor to be exploited for RA disease imaging (eg, folate-conjugated PET tracers) and
therapeutic targeting (eg, … , FRβ-targeted in vivo imaging modalities, and FRβ-directed drug …

… of cell-surface protein receptor targets, the endogenous receptors are manually … the
therapeutic ligand (quality); and (4) dual-targeting systems that characterize simultaneous targeting …

… in the drug design and discovery stages have been developed during the last several …
treatment effectiveness, and this method has resulted to the development of many folic acid–based …

… Herein, we have developed an efficient approach for folate receptor (FR) over expressed …
Discovery and development of folic-acid-Based receptor targeting for imaging and therapy of …