[HTML][HTML] Drug repositioning or target repositioning: A structural perspective of drug-target-indication relationship for available repurposed drugs

D Parisi, MF Adasme, A Sveshnikova, SN Bolz… - Computational and …, 2020 - Elsevier
drug discovery and what that implies for future developments. To address this question, we
systematically evaluated over 100 drugs, 200 target … delivering novel therapeutic agents in a …

Drug repositioning: Progress and challenges in drug discovery for various diseases

Y Hua, X Dai, Y Xu, G Xing, H Liu, T Lu, Y Chen… - European Journal of …, 2022 - Elsevier
… Particularly, it has been confirmed that drug repositioning has … drug repositioning. In this
review, we systematically reviewed a series of representative drugs that have been repositioned

A data-driven drug repositioning framework discovered a potential therapeutic agent targeting COVID-19

Y Ge, T Tian, S Huang, F Wan, J Li, S Li, H Yang… - BioRxiv, 2020 - biorxiv.org
… All these evidences indicate the possibility of repurposing PARP1 inhibitors as a safe
therapeutic agent to treat the current acute lung disease caused by SARS-CoV-2 infection. In …

An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19

Y Ge, T Tian, S Huang, F Wan, J Li, S Li… - … and targeted therapy, 2021 - nature.com
… All these evidences indicate the possibility of repurposing PARP1 inhibitors as a safe
therapeutic agent to treat the current acute lung disease caused by SARS-CoV-2 infection. In …

[HTML][HTML] Molecular interaction networks and drug development: Novel approach to drug target identification and drug repositioning

J Loscalzo - The FASEB Journal, 2023 - ncbi.nlm.nih.gov
… This approach to drug discovery offers … drug targets and drug repurposing opportunities.
As an example of disease module‐based insight into disease mechanism, consider pulmonary

Drug repurposing: a promising tool to accelerate the drug discovery process

V Parvathaneni, NS Kulkarni, A Muth, V Gupta - Drug discovery today, 2019 - Elsevier
… value in discovering novel therapeutic agents. Most notably, … drug targets for old drugs,
undiscovered drugdrug similarities … antidepressants to treat patients with small-cell lung cancer (…

[HTML][HTML] Prediction of repurposed drugs for treating lung injury in COVID-19

B He, L Garmire - F1000Research, 2020 - ncbi.nlm.nih.gov
… human lung cells treated with ACE2 inhibitor and human lungbased on the results
descriptions. If not, the conclusion "our drug repositioning pipeline has shown merit in discovering

Drug repositioning: a brief overview

JP Jourdan, R Bureau, C Rochais… - Journal of Pharmacy …, 2020 - academic.oup.com
drug discovery. [1] The history of medicine has been marked by several examples of repositioned
drugs, including some very old drugs… produces to treat pulmonary arterial hypertension…

Drug Repurposing Approach, Potential Drugs, and Novel Drug Targets for COVID‐19 Treatment

ZD Kifle, AG Ayele, EF Enyew - Journal of Environmental and …, 2021 - Wiley Online Library
… primarily focused on therapeutic agents that possessed activity … and discovery of therapeutic
agents that identifies new … pulmonary injury and pulmonary hypertension, indicating that …

Drug repurposing (DR): an emerging approach in drug discovery

M Rudrapal, SJ Khairnar, AG Jadhav - Drug repurposing …, 2020 - books.google.com
… Moreover, researchers only need 1–2 years to identify new drug targets and about an … -2
(severe acute respiratory syndrome coronavirus-2). The antiviral effect of an older antimalarial …