… of cellular functions such as cell proliferation, differentiation, … such as SHC-transforming
docking protein which is further implicated … a tumor suppressor in different cancers, its role as an …

… differentiation, thus inducing the onset of neuroblastoma. … , which function as docking sites
for downstream targets [33]. … Nearly 30 different ALK fusion proteins have been described, …

… NPCs differentiate into neurons which migrate along defined … to recruit other signaling proteins,
while ShcC and ShcD contain … distinct functions of each homolog, and how their functions …

… to neuroblastoma with large variance among different age … in expression at the different
stages of differentiation. Many miRNAs … Several studies suggested ShcC be a potent substrate of …

… of its deregulation in neuroblastoma, and current promising therapeutics targeting … cell
function as one of the central signaling axes that affect many different cellular functions (…

… of investigated tumors were distinguished: choroid plexus tumors… as a negative prognostic
marker in neuroblastoma [48,49]. … (at the 5% level) difference in the level of TrkB between CNS …

… ShcB and ShcC proteins are expressed only … proteins share a similar structure they have
different functions. p52ShcA is involved predominantly in cell proliferation, p66ShcA has a role …

… The SHC3 (known as Rai, N-Shc, ShcC) gene encodes for … In neuroblastoma cells, the
interplay between Shc3 and HIF-… assay of tumor tissues from different treatment groups of nude …

… Thus, our results suggest that different response to hypoxia maybe due, at least in part, to …
Distinct role of ShcC docking protein in the differentiation of neuroblastoma. Oncogene 28(5)…

… Neuroblastoma (NB) is clinically linked to distinct genomic … neuronal differentiation, including
neuroblastoma [57]. ZNF281 is highly expressed in stage 4 NB patients supporting a role of …