[HTML][HTML] Tumor-associated macrophages in pancreatic ductal adenocarcinoma: therapeutic opportunities and clinical challenges
AR Poh, M Ernst - Cancers, 2021 - mdpi.com
… pre-clinical models has not always translated into clinical trials. … macrophage heterogeneity
within the pancreatic tumor microenvironment, and examine the contribution of macrophages …
within the pancreatic tumor microenvironment, and examine the contribution of macrophages …
Clinical relevance of tumour-associated macrophages
MJ Pittet, O Michielin, D Migliorini - Nature reviews Clinical oncology, 2022 - nature.com
… In the past decade, substantial advances have been made in understanding the biology
of tumour-associated macrophages (TAMs), and their clinical relevance is emerging. A …
of tumour-associated macrophages (TAMs), and their clinical relevance is emerging. A …
Role of tumor-associated macrophages in the clinical course of pancreatic neuroendocrine tumors (PanNETs)
… frequent use of imaging in clinical practice (4). Similar to pancreatic ductal adenocarcinoma
(PDAC), … Scoring of B7-H3 staining also took into account its distribution on the PanNET cell …
(PDAC), … Scoring of B7-H3 staining also took into account its distribution on the PanNET cell …
[HTML][HTML] Tumor-associated macrophages in pancreatic ductal adenocarcinoma: origin, polarization, function, and reprogramming
S Yang, Q Liu, Q Liao - Frontiers in cell and developmental biology, 2021 - frontiersin.org
… parallelly compared the drug delivery efficiency of exosomes from pancreatic cancer cells, …
, the clinical significance of reducing the TAM population has been enlightened in clinical …
, the clinical significance of reducing the TAM population has been enlightened in clinical …
[HTML][HTML] Alteration of tumor-associated macrophage subtypes mediated by KRT6A in pancreatic ductal adenocarcinoma
J Zhang, H Sun, S Liu, W Huang, J Gu, Z Zhao… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
… types were distributed differently in ANT and PDAC, including M0, M1, and M2 macrophages
(… and fraction of macrophages in PDAC compared to the control pancreas in CRA001160, …
(… and fraction of macrophages in PDAC compared to the control pancreas in CRA001160, …
[HTML][HTML] Tumor-associated macrophages promote pancreatic ductal adenocarcinoma progression by inducing epithelial-to-mesenchymal transition
C Xiong, Y Zhu, M Xue, Y Jiang, Y Zhong… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
… In this study, we investigated the role of tumor-associated macrophages (TAMs) in the
progression of pancreatic ductal adenocarcinoma (PDAC). PDAC patients with higher levels of …
progression of pancreatic ductal adenocarcinoma (PDAC). PDAC patients with higher levels of …
[HTML][HTML] The immune landscape of human pancreatic ductal carcinoma: key players, clinical implications, and challenges
M Muller, V Haghnejad, M Schaefer, G Gauchotte… - Cancers, 2022 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive
and deadliest cancer worldwide, with an overall survival (OS) rate, all stages combined, of …
and deadliest cancer worldwide, with an overall survival (OS) rate, all stages combined, of …
[HTML][HTML] Integrated transcriptional analysis reveals macrophage heterogeneity and macrophage-tumor cell interactions in the progression of pancreatic ductal …
K Yang, T Yang, J Yu, F Li, X Zhao - BMC cancer, 2023 - Springer
… Notably, cluster 2 macrophages also served as the progenitor of tumor-infiltrating macrophages,
and cluster 3 macrophages were distributed broadly in the termini of State2. Further, …
and cluster 3 macrophages were distributed broadly in the termini of State2. Further, …
Spatially restricted tumour-associated and host-associated immune drivers correlate with the recurrence sites of pancreatic cancer
… Objective Most patients with pancreatic ductal … and moderate CD68 + tumour-associated
macrophages counts (cyan… displayed significant heterogeneity regarding the distribution pattern …
macrophages counts (cyan… displayed significant heterogeneity regarding the distribution pattern …
Tumor-associated macrophages (TAMs): Constructing an immunosuppressive microenvironment bridge for pancreatic ductal adenocarcinoma (PDAC)☆
R Liu, J Li, L Liu, W Wang, J Jia - Cancer Pathogenesis and Therapy, 2024 - mednexus.org
… Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease with increasing incidences
worldwide. The overall 5-year survival rate remains low, underscoring the urgent need for …
worldwide. The overall 5-year survival rate remains low, underscoring the urgent need for …