… α-helical native structure to β-sheet-rich amyloid fibrils. All three bonds remain intact throughout
the … Therefore, it follows that H-fragment monomers convert into an equimolar mixture of …

… rate of native insulin indicates that disulfide linkages have a … by converting it to peroxide
and oxygen in cells. The … of their native disulfide bond and rearrangement into amyloid fibrils. …

… defined by the presence of multiple disulfide bonds such as insulin, lysozyme, or α-… that
the native disulfide bonding is preserved in the fibrillar form (eg, ref (36)). Although there are …

… the fibril, we investigate the possibility of obtaining amyloid fibrils … disulphide bonds will
contain the proposed spine of the fibril. … fibrils are constructed from slightly modified native insulin …

… disulfide bond may constitute insulin’s major amyloid stretch … are identical with those
responsible for folding of the native … of steric zippers within insulin amyloid fibrils. The earlier …

… conditions native insulin is capable of converting into … ACC 6-11 form amyloid fibrils at low
or neutral pH during 48 h at least … However, we have shown recently that the disulfide bond …

… Conversion of soluble polypeptides into insoluble amyloid … In both peptides, insulin’s
original intrachain Cys6–Cys11 disulfide bond is retained, while the native Cys7 residue is …

… structure of a monomorphic insulin amyloid fibril that has been … the three preserved disulfide
bridges define the amyloid core … of the three native disulfide bonds are represented at the …

… of the roles of insulin disulfide bonds during the fibrillation of this … to investigate the heat
stability of insulin amyloid fibrils. … of fibrils was much more cooperative than that of native insulin. …

… conserved intramolecular disulfide bonds followed by proteolytic … conversion of soluble insulin
molecules into insoluble fibrils … structure, and cell toxicity from intact insulin amyloid fibrils. …