… fibrils (Figure 1B,C). Notably, β-cell-specific expression of hIAPP under the insulin promoter
stimulates islet amyloidosis, … To confirm that hIAPP may also interact with native membranes, …

… full-length insulin molecules assemble into amyloid fibril at the … of interactions between
non-native insulin conformations [5]. … , with an additional intrachain disulfide bridge between A6-…

… secretion of insulin and another hormone called islet amyloid … to many amyloid fibrils,
including tau, Sup35, and amyloid-β.… involved in amyloid diseases contain disulfide bonds.It is …

… Reduction of the Cys1-Cys7 disulfide bond resulted in faster … involved in the fibrillation of
native and sequence-modified hCT and … Role of aromatic residues in amyloid fibril formation of …

… In line with this, when the disulfide bond of NT MiSp was … This is in line with the notion that
amyloid fibrils can form from … proteins that undergo such conversion include insulin 49,50 , …

… the propensity to form amyloid fibrils of the region of the insulin A-… stability are disulfide bonds.
For example, addition of 3 … concentrations, HSA remains native when moderate amounts of …

… in the conversion of native proteins into amyloid fibrils (AFs) … of disulfide bridges can have a
strong impact on amyloid … such as β-amyloid (Alzheimer's), huPrP (prion), and insulin-derived …

… conversion of the oligomers into nuclei that further grow into … While native and denatured
proteins do not aggregate easily … involved in an intramolecular disulfide (SS) bond. OVA is the …

… amyloid fibrils of p16 are disaggregated by addition of reducing agent, showing that the
disulfide bond is … electrostatic effects of filamentous protein aggregation processes of insulin and …

… structure of both protein fibrils while remodeling HEWL fibril length and promoting the
formation of amorphous aggregates in the case of insulin. Although the intrinsic fluorescence …