[HTML][HTML] Schizophrenia genomics: convergence on synaptic development, adult synaptic plasticity, or both?

J Hall, NJ Bray - Biological Psychiatry, 2022 - Elsevier
… of-function and missense genetic variants in genes encoding … within a transcriptional
gene network associated with … Figure 2 shows the developmental timing of various synaptic …

Rare coding variants in ten genes confer substantial risk for schizophrenia

T Singh, T Poterba, D Curtis, H Akil, M Al Eissa… - Nature, 2022 - nature.com
… , although different mutation types are implicated in some shared genes. Most … convergence
in the genes and biological processes implicated by common and ultra-rare genetic variation

[HTML][HTML] Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk

Y Huo, S Li, J Liu, X Li, XJ Luo - Nature communications, 2019 - nature.com
genetic variations in REs affect gene expression through altering binding affinity of TFs. The
architecture and function of REs are variable in different … how genetic variants contribute to …

[HTML][HTML] Synaptic and gene regulatory mechanisms in schizophrenia, autism, and 22q11. 2 copy number variant–mediated risk for neuropsychiatric disorders

JK Forsyth, D Nachun, MJ Gandal, DH Geschwind… - Biological …, 2020 - Elsevier
… 2 are among the genetic variants most strongly associated with … for ASD additionally converge
on networks involved in early … loading highly onto gene networks that orchestrate neuronal …

Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder

EC Johnson, M Kapoor, AS Hatoum, H Zhou… - Psychological …, 2023 - cambridge.org
functional categories remains unknown, we partitioned the … only one of those exerting a
different direction of effect relative to … limited to studying common genetic variation (minor allele …

Synergistic effects of common schizophrenia risk variants

N Schrode, SM Ho, K Yamamuro, A Dobbyn… - … genetics, 2019 - nature.com
… SZ eQTL genes that converges on synaptic function. We … of these genetic variants, alone
and in combination, on geneConvergence between the various risk variants linked to …

[HTML][HTML] Endophenotypes in schizophrenia: digging deeper to identify genetic mechanisms

TA Greenwood, A Shutes-David… - Journal of psychiatry …, 2019 - ncbi.nlm.nih.gov
… and demonstrated that common genetic variants in aggregate … reviewed here converge on
a functional gene network, which … genetic studies, we can begin to piece together how various

An integrative gene network-based approach to uncover the cellular and molecular infrastructures of schizophrenia

A Bozorgmehr, B Sadeghi, EST Zavari, E Bahrami… - Life Sciences, 2020 - Elsevier
… terms of structure and function during schizophrenia pathogenesis [6]. … of the
schizophrenia-related gene set in different regions of … that genetic variation in the serotonin …

Multi-scale analysis of schizophrenia risk genes, brain structure, and clinical symptoms reveals integrative clues for subtyping schizophrenia patients

L Ma, ET Rolls, X Liu, Y Liu, Z Jiao… - Journal of molecular …, 2019 - academic.oup.com
… an integrated view of how genetic variants may affect brain … identified gene networks from
different types of schizophrenia… of genes may potentially indicate high relevance to function, we …

[HTML][HTML] Convergence of brain transcriptomic and neuroimaging patterns in schizophrenia, bipolar disorder, autism spectrum disorder, and major depressive disorder

DJ Ardesch, I Libedinsky, LH Scholtens, Y Wei… - Biological Psychiatry …, 2023 - Elsevier
Genes are known to display high variation in expression … of genes related to psychiatric
conditions may affect different … -state functional networks (Figure 4A), disorder risk genes indeed …