[PDF][PDF] Defining the genetic, genomic, cellular, and diagnostic architectures of psychiatric disorders
PF Sullivan, DH Geschwind - Cell, 2019 - cell.com
… genetic heterogeneity, both ASD risk and SCZ risk converge … different pathways than
those affected by inherited variation. … Tissue and Cellular Architecture As with gene network …
those affected by inherited variation. … Tissue and Cellular Architecture As with gene network …
Genome-wide association of endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia (COGS) study
… the gene network identified through candidate gene association … Such convergence at the
pathway level may be more likely to … Specifically, genetic variants of NRG3 are associated with …
pathway level may be more likely to … Specifically, genetic variants of NRG3 are associated with …
A Bayesian framework that integrates multi-omics data and gene networks predicts risk genes from schizophrenia GWAS data
… it can leverage data from different sources (for example, transcriptomics … network, with the
rationale that the functional convergence of risk genes, reflected in the perspective of networks…
rationale that the functional convergence of risk genes, reflected in the perspective of networks…
[HTML][HTML] Mutations associated with neuropsychiatric conditions delineate functional brain connectivity dimensions contributing to autism and schizophrenia
… distinct genetic variants … converge on overlapping intermediate brain phenotypes, consistent
with a recent study showing overlapping effects on subcortical structures across 12 different …
with a recent study showing overlapping effects on subcortical structures across 12 different …
[HTML][HTML] Non-additive effects of schizophrenia risk genes reflect convergent downstream function
… Precisely how genetic variants with individually small … -confidence co-expressed gene
networks that replicated across a … or more diverse pathways to increase SCZ variance explained), …
networks that replicated across a … or more diverse pathways to increase SCZ variance explained), …
[HTML][HTML] Genomic variation, evolvability, and the paradox of mental illness
CT Gualtieri - Frontiers in Psychiatry, 2021 - frontiersin.org
… the same genetic variant with various phenotypic expressions… Clinical studies of gene networks,
however, are theoretical, … in many different forms and at hundreds of targets converge on …
however, are theoretical, … in many different forms and at hundreds of targets converge on …
Transcriptomic networks implicate neuronal energetic abnormalities in three mouse models harboring autism and schizophrenia-associated mutations
A Gordon, A Forsingdal, IV Klewe, J Nielsen… - Molecular …, 2021 - nature.com
… expression at the level of individual genes, gene network analysis identified two cortical and
… To address whether specific genetic variants imparting major risk for SCZ or ASD converge …
… To address whether specific genetic variants imparting major risk for SCZ or ASD converge …
[HTML][HTML] What genes are differentially expressed in individuals with schizophrenia? A systematic review
AK Merikangas, M Shelly, A Knighton, N Kotler… - Molecular …, 2022 - nature.com
… Gaining insight into the mechanistic influences of these genetic variants … and rare genetic
variants, as well as diverse environmental … with specific classes of loss-of-function variants [27]. …
variants, as well as diverse environmental … with specific classes of loss-of-function variants [27]. …
Genomics, convergent neuroscience and progress in understanding autism spectrum disorder
… , or intersection, of diverse ASD genetic risks with respect to … for rare damaging variants
(case–control, schizophrenia only)… of ultra-rare genetic variation, the characterization of …
(case–control, schizophrenia only)… of ultra-rare genetic variation, the characterization of …
Converging pathways found in copy number variation syndromes with high schizophrenia risk
… contribution of these genetic variants to mental illness, we need … presentation of schizophrenia
risk genes from different sources in … search function to extract genes and genetic variants …
risk genes from different sources in … search function to extract genes and genetic variants …