Neanderthal‐derived genetic variation in living humans relates to schizophrenia diagnosis, to psychotic symptom severity, and to dopamine synthesis

MD Gregory, DP Eisenberg, M Hamborg… - … of Medical Genetics …, 2021 - Wiley Online Library
… admixture and dopamine function suggests a potential … variants, each of which alone conveys
a small risk, converge … of polygenic risk may even uncover various subgroups of disease (…

[HTML][HTML] Functional connectivity signatures of NMDAR dysfunction in schizophrenia—integrating findings from imaging genetics and pharmaco-fMRI

AJ Gaebler, N Fakour, F Stöhr, J Zweerings… - Translational …, 2023 - nature.com
… that both common and rare genetic variants associated with schizophrenia converge to … of
the genetic variant on the functional connectivity profile of different brain regions and networks

Characteristics of the effects of genetic variation in rodent models of risk for schizophrenia and neurodevelopment disorder

RL Pass - 2019 - orca.cardiff.ac.uk
Genetic investigations have converged on specific pathways, … PSD involved in the regulation
of glutamatergic functioning … This thesis aimed to characterise two different rodent models …

The three-dimensional landscape of the genome in human brain tissue unveils regulatory mechanisms leading to schizophrenia risk

W Mah, H Won - Schizophrenia research, 2020 - Elsevier
… Three distinct classes of genetic variation have been … between schizophrenia risk genes
identified in different studies has not … variation and rare variation converge onto the same set of …

Dystonia genes functionally converge in specific neurons and share neurobiology with psychiatric disorders

NE Mencacci, RH Reynolds, SG Ruiz, J Vandrovcova… - Brain, 2020 - academic.oup.com
… and schizophrenia, are frequent in patients with dystonia. While mutations in a fast-growing
number of genes have been linked to Mendelian forms … mechanisms, different from those of …

[HTML][HTML] Novel approaches for identifying the molecular background of schizophrenia

AK Golov, NV Kondratyev, GP Kostyuk, VE Golimbet - Cells, 2020 - mdpi.com
… common genetic variants associated with schizophrenia have … used type of gene network
analysis is weighted gene co-… that causal genes should converge in tight functionally related …

[HTML][HTML] How variation in risk allele output and gene interactions shape the genetic architecture of schizophrenia

M Kasap, DS Dwyer - Genes, 2022 - mdpi.com
… Some of the genetic variants associated with schizophrenia … P t converged on 0.01, the
prevalence of schizophrenia in … described the functional connectivity of gene networks in terms of …

Rare coding variants as risk modifiers of the 22q11. 2 deletion implicate postnatal cortical development in syndromic schizophrenia

JR Lin, Y Zhao, MR Jabalameli, N Nguyen, J Mitra… - Molecular …, 2023 - nature.com
… to identify risk modifying genetic variants and investigate their … framework that integrates
gene network and phenotype data … the modifier genes and 22q11.2 deletion share convergent

Parsing the functional impact of noncoding genetic variants in the brain epigenome

SK Powell, C O'Shea, KJ Brennand, S Akbarian - Biological psychiatry, 2021 - Elsevier
… ultimately converge on coordinating a 3D topology of genes … the pool of common variants
implicated in schizophrenia (24). … insights into cell type–specific associations of various types of …

Convergent evidence that ZNF804A is a regulator of pre-messenger RNA processing and gene expression

RM Chapman, CL Tinsley, MJ Hill… - Schizophrenia …, 2019 - academic.oup.com
… Here, we investigate the function of ZNF804A using a variety of … genetic variants associated
with an increased risk in … Two siRNAs targeting different exons of ZNF804A were analyzed …