Neanderthal‐derived genetic variation in living humans relates to schizophrenia diagnosis, to psychotic symptom severity, and to dopamine synthesis
MD Gregory, DP Eisenberg, M Hamborg… - … of Medical Genetics …, 2021 - Wiley Online Library
… admixture and dopamine function suggests a potential … variants, each of which alone conveys
a small risk, converge … of polygenic risk may even uncover various subgroups of disease (…
a small risk, converge … of polygenic risk may even uncover various subgroups of disease (…
[HTML][HTML] Functional connectivity signatures of NMDAR dysfunction in schizophrenia—integrating findings from imaging genetics and pharmaco-fMRI
AJ Gaebler, N Fakour, F Stöhr, J Zweerings… - Translational …, 2023 - nature.com
… that both common and rare genetic variants associated with schizophrenia converge to … of
the genetic variant on the functional connectivity profile of different brain regions and networks …
the genetic variant on the functional connectivity profile of different brain regions and networks …
Characteristics of the effects of genetic variation in rodent models of risk for schizophrenia and neurodevelopment disorder
RL Pass - 2019 - orca.cardiff.ac.uk
… Genetic investigations have converged on specific pathways, … PSD involved in the regulation
of glutamatergic functioning … This thesis aimed to characterise two different rodent models …
of glutamatergic functioning … This thesis aimed to characterise two different rodent models …
The three-dimensional landscape of the genome in human brain tissue unveils regulatory mechanisms leading to schizophrenia risk
W Mah, H Won - Schizophrenia research, 2020 - Elsevier
… Three distinct classes of genetic variation have been … between schizophrenia risk genes
identified in different studies has not … variation and rare variation converge onto the same set of …
identified in different studies has not … variation and rare variation converge onto the same set of …
Dystonia genes functionally converge in specific neurons and share neurobiology with psychiatric disorders
… and schizophrenia, are frequent in patients with dystonia. While mutations in a fast-growing
number of genes have been linked to Mendelian forms … mechanisms, different from those of …
number of genes have been linked to Mendelian forms … mechanisms, different from those of …
[HTML][HTML] Novel approaches for identifying the molecular background of schizophrenia
AK Golov, NV Kondratyev, GP Kostyuk, VE Golimbet - Cells, 2020 - mdpi.com
… common genetic variants associated with schizophrenia have … used type of gene network
analysis is weighted gene co-… that causal genes should converge in tight functionally related …
analysis is weighted gene co-… that causal genes should converge in tight functionally related …
[HTML][HTML] How variation in risk allele output and gene interactions shape the genetic architecture of schizophrenia
M Kasap, DS Dwyer - Genes, 2022 - mdpi.com
… Some of the genetic variants associated with schizophrenia … P t converged on 0.01, the
prevalence of schizophrenia in … described the functional connectivity of gene networks in terms of …
prevalence of schizophrenia in … described the functional connectivity of gene networks in terms of …
Rare coding variants as risk modifiers of the 22q11. 2 deletion implicate postnatal cortical development in syndromic schizophrenia
… to identify risk modifying genetic variants and investigate their … framework that integrates
gene network and phenotype data … the modifier genes and 22q11.2 deletion share convergent …
gene network and phenotype data … the modifier genes and 22q11.2 deletion share convergent …
Parsing the functional impact of noncoding genetic variants in the brain epigenome
SK Powell, C O'Shea, KJ Brennand, S Akbarian - Biological psychiatry, 2021 - Elsevier
… ultimately converge on coordinating a 3D topology of genes … the pool of common variants
implicated in schizophrenia (24). … insights into cell type–specific associations of various types of …
implicated in schizophrenia (24). … insights into cell type–specific associations of various types of …
Convergent evidence that ZNF804A is a regulator of pre-messenger RNA processing and gene expression
RM Chapman, CL Tinsley, MJ Hill… - Schizophrenia …, 2019 - academic.oup.com
… Here, we investigate the function of ZNF804A using a variety of … genetic variants associated
with an increased risk in … Two siRNAs targeting different exons of ZNF804A were analyzed …
with an increased risk in … Two siRNAs targeting different exons of ZNF804A were analyzed …