[HTML][HTML] Cell type and condition specific functional annotation of schizophrenia associated non-coding genetic variants
CK Rummel, M Gagliardi, A Herholt, R Ahmad, V Murek… - bioRxiv, 2023 - ncbi.nlm.nih.gov
… of NCDVs and their converging effects on key biological pathways in distinct cellular contexts.
… In this context, our results in NPCs and under various stimulation paradigms represent the …
… In this context, our results in NPCs and under various stimulation paradigms represent the …
[HTML][HTML] The inflamed brain in schizophrenia: the convergence of genetic and environmental risk factors that lead to uncontrolled neuroinflammation
… that modulate immune function. We also explore … Finally, we describe the diverse roles that
microglia play in response to … to MIA, the genetic differences between mouse strains could be …
microglia play in response to … to MIA, the genetic differences between mouse strains could be …
[HTML][HTML] … neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants
… Genetic variation in these programs is associated with … SZ common variants converge on
specific gene expression programs … Although different to the sub-types generated by our in vitro …
specific gene expression programs … Although different to the sub-types generated by our in vitro …
[HTML][HTML] Increased burden of ultra-rare structural variants localizing to boundaries of topologically associated domains in schizophrenia
M Halvorsen, R Huh, N Oskolkov, J Wen… - Nature …, 2020 - nature.com
… to schizophrenia etiology from a variety of genetic variants … of more variants, we computed
heritability in different ways by … to common variant risk, are likely to converge on higher …
heritability in different ways by … to common variant risk, are likely to converge on higher …
[HTML][HTML] A gene co-expression network-based analysis of multiple brain tissues reveals novel genes and molecular pathways underlying major depression
… study gene expression and its relationship with genetic variation, … and give higher credibility
to genes with convergent … Our analyses rely on the stability of gene networks both within and …
to genes with convergent … Our analyses rely on the stability of gene networks both within and …
Convergence of spectrums: neuronal gene network states in autism spectrum disorder
JM Sullivan, S De Rubeis, A Schaefer - Current Opinion in Neurobiology, 2019 - Elsevier
… Many of the affected genes encoded functionally distinct … that link ASD with genetic variation
in non-coding gene regulatory … that the convergence of the varied ASD risk genes onto the …
in non-coding gene regulatory … that the convergence of the varied ASD risk genes onto the …
[PDF][PDF] Getting to the cores of autism
… common genetic variants to psychiatric risk to the individual. … ASD genes show significant
functional convergence within … the relationship between gene networks and cognitive …
functional convergence within … the relationship between gene networks and cognitive …
Impact of schizophrenia GWAS loci converge onto distinct pathways in cortical interneurons vs glutamatergic neurons during development
… has opposite effects in different cell types [5, 6], … genes with smaller impacts converge onto
specific pathways; however, we were aiming to mimic functional consequences of converging …
specific pathways; however, we were aiming to mimic functional consequences of converging …
Uncovering convergence and divergence between autism and schizophrenia using genomic tools and patients' neurons
E Romanovsky, A Choudhary, AA Akel, S Stern - 2023 - researchsquare.com
… ) with the frequently reported genetic variants in SCZ 6 to … in ASD GWAS and visualized a
gene network as shown in Fig. … We also mapped the regions in the different chromosomes …
gene network as shown in Fig. … We also mapped the regions in the different chromosomes …
[HTML][HTML] Behavioural and functional evidence revealing the role of RBFOX1 variation in multiple psychiatric disorders and traits
… human common genetic variants, we confirmed gene-based … In conclusion, convergent
translational evidence shows that … to have different effects on the regulated gene networks [56], …
translational evidence shows that … to have different effects on the regulated gene networks [56], …