[HTML][HTML] Behavioural and functional evidence revealing the role of RBFOX1 variation in multiple psychiatric disorders and traits

A O'Leary, N Fernàndez-Castillo, G Gan, Y Yang… - Molecular …, 2022 - nature.com
… human common genetic variants, we confirmed gene-based … In conclusion, convergent
translational evidence shows that … to have different effects on the regulated gene networks [56], …

[HTML][HTML] Emerging methods and resources for biological interrogation of neuropsychiatric polygenic signal

E Uffelmann, D Posthuma - Biological psychiatry, 2021 - Elsevier
variants to convergence on biological function, tissue type, or … relevant for annotating genetic
variants (see also Table 1). … as well as donors with schizophrenia, major depressive disorder…

Predicting regulatory variants using a dense epigenomic mapped CNN model elucidated the molecular basis of trait-tissue associations

G Pei, R Hu, Y Dai, AM Manuel, Z Zhao… - Nucleic acids …, 2021 - academic.oup.com
… We use different genetic variant datasets to assess the … the impact of a variant with tissue or
cell-type specificity. Lastly, we … to investigate schizophrenia associated variants of functional

[HTML][HTML] Convergent Functional Genomics approach to prioritize molecular targets of risk in early life stress-related psychiatric disorders

A Cattaneo, N Cattane, C Scassellati, I D'Aprile… - Brain, Behavior, & …, 2020 - Elsevier
… these 16 genes, we have applied a gene network analysis to … of a different group of patients
affected by schizophrenia and … found that genetic variability within FoxO1 gene interacts with …

[PDF][PDF] The Oft-Overlooked massively parallel reporter assay: where, when and Which Psychiatric Genetic Variants are Functional

B Mulvey, T Lagunas, JD Dougherty - bioRxiv, 2020 - scholar.archive.org
functional variants that converge on common phenotypes. … -gene-target CRISPRi/a assay
revealed that schizophrenia … Secondly, genes and gene networks affected by statistically …

Consensus molecular environment of schizophrenia risk genes in coexpression networks shifting across age and brain regions

G Pergola, M Parihar, L Sportelli, R Bharadwaj… - Science …, 2023 - science.org
… the convergence of putative schizophrenia risk genes in brain … Interindividual genetic
variation associated with risk-… of coexpressed genes from SNPs varied across different modules, …

Thinking about schizophrenia in an era of genomic medicine

DR Weinberger - American Journal of Psychiatry, 2019 - Am Psychiatric Assoc
… The study of gene function and genetic variation generates insights … functional convergence.
The assumption here is that despite the apparent biological diversity of the implicated genes

New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications

OA Andreassen, GFL Hindley, O Frei… - World …, 2023 - Wiley Online Library
… the common genetic variance underlying schizophrenia (see … , with emerging biological
convergence across both ends of … shared between schizophrenia and various brain morphology …

Diverse types of genomic evidence converge on alcohol use disorder risk genes

Y Dai, R Hu, G Pei, H Zhang, Z Zhao… - Journal of medical genetics, 2020 - jmg.bmj.com
… These genetic variants may modulate gene expression, … the method in studying the genetics
of schizophrenia20 and Crohn’s … function to identify disease-related tissues based on genes

Examining the shared etiology of psychopathology with genome-wide association studies

TT Mallard, AD Grotzinger… - Physiological …, 2023 - journals.physiology.org
converge on shared sets of risk genes such as GRIN2A and … how these different types of
genetic variation function in … link gene networks to psychiatric risk have revealed that genetic risk …