[HTML][HTML] Behavioural and functional evidence revealing the role of RBFOX1 variation in multiple psychiatric disorders and traits
… human common genetic variants, we confirmed gene-based … In conclusion, convergent
translational evidence shows that … to have different effects on the regulated gene networks [56], …
translational evidence shows that … to have different effects on the regulated gene networks [56], …
[HTML][HTML] Emerging methods and resources for biological interrogation of neuropsychiatric polygenic signal
E Uffelmann, D Posthuma - Biological psychiatry, 2021 - Elsevier
… variants to convergence on biological function, tissue type, or … relevant for annotating genetic
variants (see also Table 1). … as well as donors with schizophrenia, major depressive disorder…
variants (see also Table 1). … as well as donors with schizophrenia, major depressive disorder…
Predicting regulatory variants using a dense epigenomic mapped CNN model elucidated the molecular basis of trait-tissue associations
… We use different genetic variant datasets to assess the … the impact of a variant with tissue or
cell-type specificity. Lastly, we … to investigate schizophrenia associated variants of functional …
cell-type specificity. Lastly, we … to investigate schizophrenia associated variants of functional …
[HTML][HTML] Convergent Functional Genomics approach to prioritize molecular targets of risk in early life stress-related psychiatric disorders
A Cattaneo, N Cattane, C Scassellati, I D'Aprile… - Brain, Behavior, & …, 2020 - Elsevier
… these 16 genes, we have applied a gene network analysis to … of a different group of patients
affected by schizophrenia and … found that genetic variability within FoxO1 gene interacts with …
affected by schizophrenia and … found that genetic variability within FoxO1 gene interacts with …
[PDF][PDF] The Oft-Overlooked massively parallel reporter assay: where, when and Which Psychiatric Genetic Variants are Functional
B Mulvey, T Lagunas, JD Dougherty - bioRxiv, 2020 - scholar.archive.org
… functional variants that converge on common phenotypes. … -gene-target CRISPRi/a assay
revealed that schizophrenia … Secondly, genes and gene networks affected by statistically …
revealed that schizophrenia … Secondly, genes and gene networks affected by statistically …
Consensus molecular environment of schizophrenia risk genes in coexpression networks shifting across age and brain regions
… the convergence of putative schizophrenia risk genes in brain … Interindividual genetic
variation associated with risk-… of coexpressed genes from SNPs varied across different modules, …
variation associated with risk-… of coexpressed genes from SNPs varied across different modules, …
Thinking about schizophrenia in an era of genomic medicine
DR Weinberger - American Journal of Psychiatry, 2019 - Am Psychiatric Assoc
… The study of gene function and genetic variation generates insights … functional convergence.
The assumption here is that despite the apparent biological diversity of the implicated genes…
The assumption here is that despite the apparent biological diversity of the implicated genes…
New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications
… the common genetic variance underlying schizophrenia (see … , with emerging biological
convergence across both ends of … shared between schizophrenia and various brain morphology …
convergence across both ends of … shared between schizophrenia and various brain morphology …
Diverse types of genomic evidence converge on alcohol use disorder risk genes
… These genetic variants may modulate gene expression, … the method in studying the genetics
of schizophrenia20 and Crohn’s … function to identify disease-related tissues based on genes …
of schizophrenia20 and Crohn’s … function to identify disease-related tissues based on genes …
Examining the shared etiology of psychopathology with genome-wide association studies
TT Mallard, AD Grotzinger… - Physiological …, 2023 - journals.physiology.org
… converge on shared sets of risk genes such as GRIN2A and … how these different types of
genetic variation function in … link gene networks to psychiatric risk have revealed that genetic risk …
genetic variation function in … link gene networks to psychiatric risk have revealed that genetic risk …