… The results showed dose- and schedule-dependent inhibition of tumor growth at doses
lower than other analogs.73 Compound 20 also exhibited excellent kinase selectivity when …

… for rapamycin's anti-neoplastic effects. The immunologic response to rapamycin is at least
partially dependent on the dose and … These dose-dependent and schedule-dependent effects …

… inhibition seemed to elicit a differential MAPK activation depending on the specific dose and
… Rapamycin treatment relieves this feedback inhibition as Grb10 becomes destabilised [78,…

… Because Mycobacterium tuberculosis modulates mammalian target of rapamycin (mTOR) …
inhibited PC3 prostate xenograft tumor growth in a dose- and schedule-dependent manner at …

… )/AKT/mammalian target of rapamycin (mTOR) signaling in cancer as a potential target for
new … about the structure and function of the mTOR pathway and discuss the mechanisms of its …

… First, we introduce landmark discoveries demonstrating mTOR as the target of rapamycin
and the … that TOR is a bona fide target of and inhibited by the FKBP12–rapamycin complex. …

… of resistance signaling pathways of mTOR inhibitor, suggesting a novel strategy to enhance
mTOR-targeted cancer therapy through combining mitoxantrone, an eEF-2K inhibitor. …

… mammalian target of rapamycin … MCF-7 cells with increased doses of rapamycin within 3
months. We showed that rapamycin caused a dose-dependent inhibition of the growth of MCF-7 …

… Multiple mechanisms and molecular targets (… Rapamycin serves as a well-known mTOR
inhibitor, and we hypothesized that the mTOR signaling pathway may be involved in rapamycin-…

… of the mammalian target of rapamycin (mTOR) pathway is … but agents that inhibit this
pathway, including mTOR inhibitors, … for pharmacokinetic assessments pre-dose and at 2 and 5 …