[HTML][HTML] Potential of histone deacetylase inhibitors in the control and regulation of prostate, breast and ovarian cancer

SD Pramanik, A Kumar Halder, U Mukherjee… - Frontiers in …, 2022 - frontiersin.org
… or chemotherapy require newer therapeutic agents. By improving the … cancer cells in 2006,
compared to lung and colon cancer … inhibitors such sirtinol, cambinol, EX527, and suramin. By …

Targeting the RNA-binding protein HuR in cancer

JM Finan, TL Sutton, DA Dixon, JR Brody - Cancer Research, 2023 - AACR
… inhibitors of translocation may be less toxic through … gene in human colon cancer cells
under oxidative stress. Mol … Suramin, screened from an approved drug library, inhibits HuR …

New theobromine derivatives inhibiting VEGFR-2: design, synthesis, antiproliferative, docking and molecular dynamics simulations

HA Mahdy, H Elkady, MS Taghour, A Elwan… - Future Medicinal …, 2023 - Future Science
… was able to induce apoptosis in colorectal cancer [28] and to … were found to have a low
toxicity profile based on the in silico … receptor antagonists suramin and theobromine on tumor-…

Recent advances in novel drug delivery systems and approaches for management of breast cancer: A comprehensive review

U Hani, M Rahamathulla, RA Osmani, HY Kumar… - Journal of Drug Delivery …, 2020 - Elsevier
… Silica NPs loaded with dual drugs (PTX and suramin) using … MCF-7 BC cells and human
colorectal cancer cells [155] … Micelles are a therapeutic agent or a carrier to deliver a poorly …

Discovery of 5-(or 6)-benzoxazoles and oxazolo [4, 5-b] pyridines as novel candidate antitumor agents targeting hTopo IIα

E Karatas, E Foto, T Ertan-Bolelli, G Yalcin-Ozkat… - Bioorganic …, 2021 - Elsevier
… Discovery of novel anticancer drugs which have low toxicity … and Topo II (aclarubicin and
suramin), stabilize noncovalent DNA … In the present study, it has been observed that the most …

Retrospective Review of Chromane Analogues as Anti-protozoal Leads: A Decade's Worth of Evolution

SR Jadhav, B Karan Kumar, RP Joshi… - Current Topics in …, 2023 - ingentaconnect.com
… The parasite selectively takes up suramin via receptor-… Genistein induces apoptosis in HT29
colon cancer cells by reducing … It is also a good therapeutic agent for wound healing [92]. …

A third shot at EGFR: new opportunities in cancer therapy

S Guardiola, M Varese, M Sanchez-Navarro… - Trends in …, 2019 - cell.com
… the therapeutic progress achieved with these drugs has been … in cell proliferation, migration,
and differentiation pathways [ … Two classes of anti-EGFR drugs are currently on the market …

Insight into small-molecule inhibitors targeting extracellular nucleotide pyrophosphatase/phosphodiesterase1 for potential multiple human diseases

B Du, J Ru, Z Zhan, C Lin, Y Liu, W Mao… - European Journal of …, 2024 - Elsevier
… Blue 2 (2) and suramin (3) exhibit low selectivity for ENPP1, as … as cancer therapeutic agents
and vaccine adjuvants [42]. … good inhibition of HT-49 colon cancer cells (IC 50 = 1.4 μM). …

Death‐associated protein kinase (DAPK) family modulators: current and future therapeutic outcomes

AK Farag, EJ Roh - Medicinal research reviews, 2019 - Wiley Online Library
… , as well as the LAR activators (suramin derivatives), could be … neuronal cell death after stroke
and brain ischemia provideshuman breast cancer, and SW480 colon cancer cell lines.187 …

Employment of enhanced permeability and retention effect (EPR): Nanoparticle-based precision tools for targeting of therapeutic and diagnostic agent in cancer

D Kalyane, N Raval, R Maheshwari, V Tambe… - Materials Science and …, 2019 - Elsevier
… to deliver the therapeutic agent at specified cancer tissue site … decrease in death rate in
patients with colon cancer [44]. … like suramin, thrombospondin, thalidomide, endostatin, and …