… , ie, self-renewal and differentiation potential, suggesting that they can drive cancer progression.
… Quiescent stem cells can respond to stimuli from their niche by activating molecular and …

… pathway is found to be upregulated and Wnt-driven autocrine production of IL-8 and IL-1β …
maintaining stemness, enhancing therapy resistance, and promoting a hypoxic niche [79]. …

… detect tumor cells responding to TGF-β in HRAS-driven primary … cellular and molecular
basis for establishing a CSC niche that promoted the malignant progression and drug resistance …

… Cancer stem cells activate a set of molecular pathways some of which are triggered by the
unique … thought to be accountable for tumor initiation, heterogeneity, drug resistance and …

… CSCs can quickly proliferate and expand from their niche or adopt a quiescent (or dormant)
phenotype.ix… Several studies show that the acquisition of resistance is powered by increased …

… amounts of ABC transporters in various cancers leading to drug resistance [84]. Hematopoietic
… Both stem cells and CSCs reside in a niche, a tumor microenvironment that regulates …

… Drug resistance and cancer relapse are occurred due to the presence of a type of stem cells
called cancer stem cells (CSCs) … in order to support niche giving resistance to therapy [59]. …

… The residual stem-like cell populations can drive a more … Cancer stem cells (CSCs),
which were discovered and developed over the past decades, play a major role in drug-resistance …

… of drug resistance as well as understanding the cross-talk between CSCs and their niche
is … formation ability, triggered higher ROS levels, and induced higher levels of apoptosis in …

… There has been a great deal of debate on how CSCs originate. Clonal evolution theory and
the cancer stem cell … reduce bCSC-driven drug resistance, interfere with their stemness, and …