Transcription-associated cyclin-dependent kinases as targets and biomarkers for cancer therapy

J Chou, DA Quigley, TM Robinson, FY Feng… - Cancer discovery, 2020 - AACR
… to promote transcription activation and regulates gene … observed at the transcriptional start
site (TSS), along the gene body, … work investigating whether this also occurs in human cancer

High-throughput transcriptome profiling in drug and biomarker discovery

X Yang, L Kui, M Tang, D Li, K Wei, W Chen… - Frontiers in …, 2020 - frontiersin.org
… this study showed that the new method for drug screening is … for cancer treatment at present,
but chemotherapeutic drug-… of chromatin and transcription to investigate the treatment of …

Identification of prognostic biomarker signatures and candidate drugs in colorectal cancer: insights from systems biology analysis

MR Rahman, T Islam, E Gov, B Turanli, G Gulfidan… - Medicina, 2019 - mdpi.com
… : This study presents biomarkerhuman transcriptional and post-transcriptional regulatory
network [37], consisting of the experimentally verified TF–target gene and miRNA–target gene

Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy

Y Lu, YT Chan, HY Tan, S Li, N Wang, Y Feng - Molecular cancer, 2020 - Springer
… Latest study of genomic and epigenomic landscape in … that miRNAs become biomarkers of
multiple cancers as their … the AR gene and repress transcription of the AR targeted genes PSA …

Transcription factors in cancer development and therapy

K Vishnoi, N Viswakarma, A Rana, B Rana - Cancers, 2020 - mdpi.com
cancer biomarker [53]. Increased glucose consumption by … breast cancer treatment and are
under clinical investigation for … at the forefront of anticancer drug discovery. The two isoforms …

HSF1 as a cancer biomarker and therapeutic target

RL Carpenter, Y Gökmen-Polar - Current cancer drug targets, 2019 - ingentaconnect.com
investigated as a biomarker for patient outcomes in multiple … pausing and promote transcription
elongation of target genes. … to promote cell survival in response to cancer treatments. …

Let-7 as biomarker, prognostic indicator, and therapy for precision medicine in cancer

E Chirshev, KC Oberg, YJ Ioffe… - … and translational medicine, 2019 - Springer
… to genomic deletions and abnormal transcription, rather than loss … The patients in this study
were treated between 1991 and … of cancer treatments by using lower chemotherapy dosages. …

ROCplot. org: Validating predictive biomarkers of chemotherapy/hormonal therapy/anti‐HER2 therapy using transcriptomic data of 3,104 breast cancer patients

JT Fekete, B Győrffy - International journal of cancer, 2019 - Wiley Online Library
… In cancer treatment, two major types of biomarkers can be … In our study, we report an online
platform enabling the … against chemotherapy treatments by blocking the transcription of TP53.…

Nuclear receptors: recent drug discovery for cancer therapies

L Zhao, S Zhou, JÅ Gustafsson - Endocrine reviews, 2019 - academic.oup.com
… Nuclear receptors (NRs) are transcription factors actively involved in many aspects of human
… domains, reflected in the exon/intron organization of the gene (4). Each NR achieves its …

The SWI/SNF complex in cancer—biology, biomarkers and therapy

P Mittal, CWM Roberts - Nature reviews Clinical oncology, 2020 - nature.com
… Consequently, increasing research interest is being focused on … SWI/SNF gene mutations
simply impair transcriptional control, … Drug screens coupled with functional genomic depletion …