Transcription-associated cyclin-dependent kinases as targets and biomarkers for cancer therapy
… to promote transcription activation and regulates gene … observed at the transcriptional start
site (TSS), along the gene body, … work investigating whether this also occurs in human cancer …
site (TSS), along the gene body, … work investigating whether this also occurs in human cancer …
High-throughput transcriptome profiling in drug and biomarker discovery
… this study showed that the new method for drug screening is … for cancer treatment at present,
but chemotherapeutic drug-… of chromatin and transcription to investigate the treatment of …
but chemotherapeutic drug-… of chromatin and transcription to investigate the treatment of …
Identification of prognostic biomarker signatures and candidate drugs in colorectal cancer: insights from systems biology analysis
… : This study presents biomarker … human transcriptional and post-transcriptional regulatory
network [37], consisting of the experimentally verified TF–target gene and miRNA–target gene …
network [37], consisting of the experimentally verified TF–target gene and miRNA–target gene …
Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy
Y Lu, YT Chan, HY Tan, S Li, N Wang, Y Feng - Molecular cancer, 2020 - Springer
… Latest study of genomic and epigenomic landscape in … that miRNAs become biomarkers of
multiple cancers as their … the AR gene and repress transcription of the AR targeted genes PSA …
multiple cancers as their … the AR gene and repress transcription of the AR targeted genes PSA …
Transcription factors in cancer development and therapy
… cancer biomarker [53]. Increased glucose consumption by … breast cancer treatment and are
under clinical investigation for … at the forefront of anticancer drug discovery. The two isoforms …
under clinical investigation for … at the forefront of anticancer drug discovery. The two isoforms …
HSF1 as a cancer biomarker and therapeutic target
RL Carpenter, Y Gökmen-Polar - Current cancer drug targets, 2019 - ingentaconnect.com
… investigated as a biomarker for patient outcomes in multiple … pausing and promote transcription
elongation of target genes. … to promote cell survival in response to cancer treatments. …
elongation of target genes. … to promote cell survival in response to cancer treatments. …
Let-7 as biomarker, prognostic indicator, and therapy for precision medicine in cancer
E Chirshev, KC Oberg, YJ Ioffe… - … and translational medicine, 2019 - Springer
… to genomic deletions and abnormal transcription, rather than loss … The patients in this study
were treated between 1991 and … of cancer treatments by using lower chemotherapy dosages. …
were treated between 1991 and … of cancer treatments by using lower chemotherapy dosages. …
ROCplot. org: Validating predictive biomarkers of chemotherapy/hormonal therapy/anti‐HER2 therapy using transcriptomic data of 3,104 breast cancer patients
… In cancer treatment, two major types of biomarkers can be … In our study, we report an online
platform enabling the … against chemotherapy treatments by blocking the transcription of TP53.…
platform enabling the … against chemotherapy treatments by blocking the transcription of TP53.…
Nuclear receptors: recent drug discovery for cancer therapies
L Zhao, S Zhou, JÅ Gustafsson - Endocrine reviews, 2019 - academic.oup.com
… Nuclear receptors (NRs) are transcription factors actively involved in many aspects of human
… domains, reflected in the exon/intron organization of the gene (4). Each NR achieves its …
… domains, reflected in the exon/intron organization of the gene (4). Each NR achieves its …
The SWI/SNF complex in cancer—biology, biomarkers and therapy
P Mittal, CWM Roberts - Nature reviews Clinical oncology, 2020 - nature.com
… Consequently, increasing research interest is being focused on … SWI/SNF gene mutations
simply impair transcriptional control, … Drug screens coupled with functional genomic depletion …
simply impair transcriptional control, … Drug screens coupled with functional genomic depletion …